2013-05-25T03:04:59Z http://repub.eur.nl/oai

oai:repub.eur.nl/res/pub/10022 2013-01-31T13:15:36Z org:9833 org:9755 org:9819 org:9746 access:open type:article

urn:NBN:nl:ui:15-1765/10022 2013-01-31T13:15:36 mods http://hdl.handle.net/1765/10022 hdl:1765/10022 urn:NBN:nl:ui:15-1765/10022 Vitamin B12, folate, and homocysteine in depression: the Rotterdam Study text article http://hdl.handle.net/1765/10022 http://repub.eur.nl/res/pub/10022/12450964.pdf application/pdf Filesize: 75 KB born digital OBJECTIVE: The associations of vitamin B(12), folate, and homocysteine with depression were examined in a population-based study. METHOD: The authors screened 3,884 elderly people for depressive symptoms. Subjects with positive screening results had psychiatric workups. Folate, vitamin B(12), and homocysteine blood levels were compared in 278 persons with depressive symptoms, including 112 with depressive disorders, and 416 randomly selected reference subjects. Adjustments were made for age, gender, cardiovascular disease, and functional disability. RESULTS: Hyperhomocysteinemia, vitamin B(12) deficiency, and to a lesser extent, folate deficiency were all related to depressive disorders. For folate deficiency and hyperhomocysteinemia, the association with depressive disorders was substantially reduced after adjustment for functional disability and cardiovascular disease, but for vitamin B(12) this appeared independent. CONCLUSIONS: The association of vitamin B(12) and folate with depressive disorders may have different underlying mechanisms. Vitamin B(12) may be causally related to depression, whereas the relation with folate is due to physical comorbidity. Tiemeier, H. Tiemeier Henning aut Tuijl, H.R. van Tuijl, van Ruud aut Meijer, J. Meijer John aut Kiliaan, A.J. Kiliaan Amanda aut Breteler, M.M.B. Breteler Monique aut Hofman, A. Hofman Albert aut 217402208 108068412 069249733 Erasmus MC: University Medical Center Rotterdam Supporting host sht en English The American Journal of Psychiatry 0002-953X 2002-01-01 Male Aged Female Humans Middle aged Research Support, Non-U.S. Gov't Chromatography, High Pressure Liquid Depressive Disorder/*complications Folic Acid Deficiency/*complications Hyperhomocysteinemia/blood/*complications Population Surveillance Vitamin B 12 Deficiency/*complications Erasmus University Rotterdam oai:repub.eur.nl/res/pub/10022 IR OAIPMH feed (http://repub.eur.nl/oai) 2007-05-08T13:12:09Z 2011-11-23T09:59:13Z http://purl.org/eprint/accessRights/OpenAccess