2013-05-19T13:09:21Z http://repub.eur.nl/oai

oai:repub.eur.nl/res/pub/22475 2012-11-14T12:24:05Z org:9825 org:9831 org:9802 org:9755 org:9804 org:9746 access:open type:article

urn:NBN:nl:ui:15-1765/22475 2012-11-14T12:24:05 mods http://hdl.handle.net/1765/22475 hdl:1765/22475 urn:NBN:nl:ui:15-1765/22475 doi:10.1136/jnnp.2005.067447 Insulin-like growth factor I promoter polymorphism, risk of stroke, and survival after stroke: the Rotterdam study text article http://hdl.handle.net/1765/22475 http://repub.eur.nl/res/pub/22475/Publisher%27s%20version.url.txt http://repub.eur.nl/res/pub/22475/16361587.pdf BACKGROUND AND PURPOSE: Low levels of insulin-like growth factor I (IGF-I) predispose to atherosclerosis and may therefore increase the risk of stroke. Low levels have also been found to influence the outcome of cardiovascular and cerebrovascular disease. A polymorphism in the promoter region of the IGF-I gene influences IGF-I levels. Non-carriers of the 192 bp allele have lower levels of IGF-I compared with 192 bp allele carriers. We studied the IGF-I polymorphism in relation to the risk of stroke and survival after stroke. METHODS: We studied 6808 subjects of the Rotterdam Study, who were followed for the occurrence of stroke and death after stroke. Subjects were grouped according to the 192 bp allele of IGF-I into non-carriers, heterozygotes, and homozygotes. The risk of stroke and survival after stroke was studied using Cox regression analysis, adjusting for age and sex, with homozygotes for the wildtype allele as the reference. RESULTS: Non-carriers had a relative risk of 0.8 (95% CI: 0.6 to 1.0) for the occurrence of any stroke and 0.7 (95% CI: 0.5 to 1.0) for ischaemic stroke. For non-carriers, the relative risk of death after any stroke was 1.5 (95% CI: 1.0 to 2.2). After an ischaemic stroke, this relative risk was 1.5 (95% CI: 0.9 to 2.6) and after a haemorrhagic stroke 5.2 (95% CI: 1.3 to 21.5). CONCLUSIONS: Our study suggests that IGF-I is a significant determinant of survival after stroke. Rijn, M.J.E. van Rijn, van Marie Josee aut Slooter, A.J.C. Slooter Arjen aut Bos, M.J. Bos Michiel aut Catarino, C.F.B.S. Catarino C.F.B.S. aut Koudstaal, P.J. Koudstaal Peter aut Hofman, A. Hofman Albert aut Breteler, M.M.B. Breteler Monique aut Duijn, C.M. van Duijn, van Cock aut 298686090 074759663 069249733 108068412 085431621 Erasmus MC: University Medical Center Rotterdam Supporting host sht en English Journal of Neurology, Neurosurgery and Psychiatry: an international peer-reviewed journal for health professionals and researchers in all areas of neurology and neurosurgery 0022-3050 77 1 24 27 2006-01-01 Male Aged Female Humans Follow-Up Studies Risk Factors Polymorphism, Genetic Regression Analysis Survival Rate Alleles Insulin-Like Growth Factor I/*genetics Promoter Regions, Genetic/*genetics Stroke/*genetics/*mortality Erasmus University Rotterdam oai:repub.eur.nl/res/pub/22475 IR OAIPMH feed (http://repub.eur.nl/oai) 2011-02-14T09:07:52Z 2011-11-23T09:59:13Z http://purl.org/eprint/accessRights/OpenAccess http://purl.org/eprint/accessRights/OpenAccess