2013-05-25T05:16:37Z http://repub.eur.nl/oai

oai:repub.eur.nl/res/pub/25673 2013-01-31T12:32:08Z org:9755 org:9797 org:9831 org:9746 access:open type:article

urn:NBN:nl:ui:15-1765/25673 2013-01-31T12:32:08 mods http://hdl.handle.net/1765/25673 hdl:1765/25673 urn:NBN:nl:ui:15-1765/25673 doi:10.1007/s10654-009-9406-z The association of serum testosterone levels and ventricular repolarization text article http://hdl.handle.net/1765/25673 http://repub.eur.nl/res/pub/25673/19957021_OA.pdf application/pdf Filesize: 219 KB born digital It is assumed that testosterone is an important regulator of gender-related differences in ventricular repolarization. Therefore, our aim was to study whether serum levels of testosterone are associated with QTc, QT and RR interval variation. Setting: two independent population-based cohort studies. Participants: 445 male participants (≥ 55 years) from the Rotterdam study cohort and 1,428 male participants from the study of health in Pomerania (SHIP) with an electrocardiogram who were randomly sampled for assessment of serum testosterone at baseline, after exclusion of participants with testosterone altering drugs, QTc prolonging drugs or dig(it)oxin, left ventricular hypertrophy and left and right bundle branch block. Endpoints: length of the QTc, QT and RR intervals. Analysis: linear regression model, adjusted for the two individual studies and a pooled analysis of both studies. The pooled analysis of the Rotterdam study and SHIP showed that the QTc interval gradually decreased among the tertiles (P value for trend 0.024). The third tertile of serum testosterone was associated with a lower QTc interval compared to the first tertile [-3.4 ms (-6.5; -0.3)]. However, the third tertile of serum testosterone was not associated with a lower QT interval compared to the first tertile [-0.7 ms (-3.1; 1.8)]. The RR interval gradually increased among the tertiles (P value for trend 0.002) and the third tertile of serum testosterone showed an increased RR interval compared to the first tertile [33.5 ms (12.2; 54.8)]. In the pooled analysis of two population-based studies, serum testosterone levels were not associated with the QT interval, which could be due to a lack of power. Lower QTc intervals in men with higher serum testosterone levels could be due to the association of serum testosterone with prolongation of the RR interval. Noord, C. van Noord, van Charlotte aut Dörr, M. Dörr Marcus aut Sturkenboom, M.C.J.M. Sturkenboom Miriam aut Straus, S.M. Straus Sabine aut Reffelmann, T. Reffelmann Thorsten aut Felix, S.B. Felix Stephan aut Hofman, A. Hofman Albert aut Kors, J.A. Kors Jan aut Haring, R. Haring Robin aut Jong, F.H. de Jong, de Frank aut Nauck, M. Nauck Matthias aut Uitterlinden, A.G. Uitterlinden André aut Wallaschofski, H. Wallaschofski Henri aut Witteman, J.C.M. Witteman Jacqueline aut Völzke, H. Völzke Henry aut Stricker, B.H.Ch. Stricker Bruno aut 139134964 069249733 091463637 073753548 104713968 07101876X 072967048 Erasmus MC: University Medical Center Rotterdam Supporting host sht en English European Journal of Epidemiology 0393-2990 25 1 21 28 2010-01-01 QTc interval RR interval Serum testosterone Ventricular repolarization Erasmus University Rotterdam oai:repub.eur.nl/res/pub/25673 IR OAIPMH feed (http://repub.eur.nl/oai) 2011-08-18T15:00:23Z 2013-01-04T11:49:48Z http://purl.org/eprint/accessRights/OpenAccess