2013-05-22T08:12:22Z http://repub.eur.nl/oai

oai:repub.eur.nl/res/pub/29515 2012-11-14T12:29:34Z org:9809 org:9755 org:9833 org:9746 access:open type:article

urn:NBN:nl:ui:15-1765/29515 2012-11-14T12:29:34 mods http://hdl.handle.net/1765/29515 hdl:1765/29515 urn:NBN:nl:ui:15-1765/29515 doi:10.1093/humrep/den062 Does confined placental mosaicism account for adverse perinatal outcomes in IVF pregnancies? text article http://hdl.handle.net/1765/29515 http://dx.doi.org/10.1093/humrep/den062 text/html born digital BACKGROUND: IVF singletons have poorer perinatal outcomes than singletons from spontaneous conceptions. This may be due to the influence of ovarian stimulation on the chromosomal constitution of the embryos which could be translated into localized chromosomal anomalies in the placenta. The aim of this study was to compare the incidence of confined placental mosaicism (CPM) in IVF/ICSI pregnancies and spontaneous conceptions. METHODS: We conducted a multi-centre retrospective analysis of karyotype results obtained by chorionic villus sampling (CVS), performed due to advanced maternal age (≥36 years at 18 weeks of gestation), in the Netherlands between 1995 and 2005. RESULTS: From a total of 322 246 pregnancies, 20 885 CVS results were analysed: 235 in the IVF/ICSI group and 20 650 in the control group. The mean age of women in both groups was 38.4 years (mean difference -0.08, 95% CI -0.35 to 0.18). Data relating to the fetal karyotype were missing in 143 cases in the control group. When taking into account missing data, the incidence of CPM was lower in the IVF-ICSI group than in the control group, 1.3% versus 2.2% (odds ratio 0.59, 95% CI 0.19-1.85), whereas the incidence of fetal chromosomal anomalies was increased 4.3% versus 2.4% (odds ratio 1.81, 95% CI 0.95-3.42). Neither differences were statistically significant. CONCLUSIONS: The incidence of CPM is not increased in IVF/ICSI pregnancies compared with spontaneous conceptions. CPM probably does not account for the adverse perinatal outcomes following IVF/ICSI. Jacod, B.C. Jacod B.C. aut Lichtenbelt, K.D. Lichtenbelt Klaske aut Schuring-Blom, G.H. Schuring-Blom Heleen aut Laven, J.S.E. Laven Joop aut Opstal, D. van Opstal, van Diane aut Eijkemans, M.J.C. Eijkemans René aut Macklon, N.S. Macklon Nick aut 090803922 156353253 298677458 Erasmus MC: University Medical Center Rotterdam Supporting host sht en English Human Reproduction 0268-1161 23 5 1107 1112 2008-05-01 IVF CPM CVS Perinatal outcomes Preimplantation genetic screening Erasmus University Rotterdam oai:repub.eur.nl/res/pub/29515 IR OAIPMH feed (http://repub.eur.nl/oai) 2011-11-22T15:59:50Z 2012-02-22T09:42:37Z http://purl.org/eprint/accessRights/OpenAccess