2013-05-25T14:46:59Z http://repub.eur.nl/oai

oai:repub.eur.nl/res/pub/8785 2013-03-13T14:53:49Z org:9755 org:9746 access:open type:article

urn:NBN:nl:ui:15-1765/8785 2013-03-13T14:53:49 mods http://hdl.handle.net/1765/8785 hdl:1765/8785 urn:NBN:nl:ui:15-1765/8785 QTc dispersion predicts cardiac mortality in the elderly: the Rotterdam Study text article http://hdl.handle.net/1765/8785 http://repub.eur.nl/res/pub/8785/9490242.pdf http://repub.eur.nl/res/pub/8785/Publishers%20version.url.txt BACKGROUND: Increased QTc dispersion has been associated with an increased risk for ventricular arrhythmias and cardiac death in selected patient populations. We examined the association between computerized QTc-dispersion measurements and mortality in a prospective analysis of the population-based Rotterdam Study among men and women aged > or = 55 years. METHODS AND RESULTS: QTc dispersion was computed with the use of the Modular ECG Analysis System as the difference between the maximum and minimum QTc intervals in 12 and 8 leads (ie, the 6 precordial leads, the shortest extremity lead, and the median of the 5 other extremity leads). After exclusion of those without a digitally stored ECG, the population consisted of 2358 men and 3454 women. During the 3 to 6.5 years (mean, 4 years) of follow-up, 568 subjects (9.8%) died. The degree of QTc dispersion was categorized into tertiles. Data were analyzed using the Cox proportional hazards model, with adjustment for age. For QTc dispersion in 8 leads, those in the highest tertile relative to the lowest tertile had a twofold risk for cardiac death (hazard ratio, 2.5; 95% confidence interval [CI], 1.6 to 4.0) and sudden cardiac death (hazard ratio, 1.9; 95% CI, 1.0 to 3.7) and a 40% increased risk for total mortality (hazard ratio, 1.4; 95% CI, 1.2 to 1.8). Additional adjustment for potential confounders, including history of myocardial infarction, hypertension, and overall QTc, did not materially change the risk estimates. Hazard ratios for QTc dispersion in 12 leads were comparable to those found for QTc dispersion in 8 leads. CONCLUSIONS: QTc dispersion is an important predictor of cardiac mortality in older men and women. Bruyne, M.C. de Bruyne, de Martine aut Hoes, A.W. Hoes Arno aut Kors, J.A. Kors Jan aut Bemmel, J.H. van Bemmel, van Jan aut Grobbee, D.E. Grobbee Diederick aut Hofman, A. Hofman Albert aut 091463637 073383376 071889256 069249733 Erasmus MC: University Medical Center Rotterdam Supporting host sht en English Circulation (Baltimore) 0009-7322 97 5 467 472 1998-01-01 Male Aged Cohort Studies Female Forecasting Humans Follow-Up Studies Risk Factors Age Factors Heart Rate/physiology Electrocardiography/*methods Arrhythmia/mortality/physiopathology Death, Sudden, Cardiac/*etiology Erasmus University Rotterdam oai:repub.eur.nl/res/pub/8785 IR OAIPMH feed (http://repub.eur.nl/oai) 2007-02-21T14:30:47Z 2011-11-21T10:30:32Z http://purl.org/eprint/accessRights/OpenAccess http://purl.org/eprint/accessRights/OpenAccess