2013-05-22T10:17:51Z http://repub.eur.nl/oai

oai:repub.eur.nl/res/pub/9058 2013-03-29T13:31:41Z org:9755 org:9746 access:open type:article

urn:NBN:nl:ui:15-1765/9058 2013-03-29T13:31:41 mods http://hdl.handle.net/1765/9058 hdl:1765/9058 urn:NBN:nl:ui:15-1765/9058 Menopausal status and distensibility of the common carotid artery text article http://hdl.handle.net/1765/9058 http://repub.eur.nl/res/pub/9058/10073978.pdf application/pdf Filesize: 320 KB born digital Although several studies have shown that exogenous estrogens have beneficial effects on arterial characteristics, the effect of endogenous estrogen on the vascular system is still unknown. In this study, distensibility, an indicator of arterial elasticity, of the common carotid artery was compared in pre- and postmenopausal women. The study comprised 93 premenopausal and 93 postmenopausal women of similar age (range, 43 to 55 years). Women were selected from respondents to a mailed questionnaire about the menopause, which was sent to all women aged 40 to 60 years in the Dutch town of Zoetermeer (n=12 675). Postmenopausal women who were at least 3 years past natural menopause or whose menses had stopped naturally before age 48, were age-matched with premenopausal women with regular menses and without menopausal complaints. The selection aimed at maximizing the contrast in estrogen status between pre- and postmenopausal women of the same age. Distensibility of the carotid artery was measured noninvasively with B-mode ultrasound and a vessel wall movement detector system. Arterial distensibility is expressed as the change in arterial diameter (distension, DeltaD) with the cardiac cycle, adjusted for lumen diameter, pulse pressure, and mean arterial blood pressure. Compared with premenopausal women, postmenopausal women had significantly lower arterial distension (DeltaD 370.5 microm [SE 9.5] versus 397.3 microm [SE 9.6]). These results suggest that the distensibility of the common carotid artery is negatively affected by natural menopause in presumed healthy women. Westendorp, I.C.D. Westendorp Iris aut Bots, M.L. Bots Michiel aut Grobbee, D.E. Grobbee Diederick aut Reneman, R.S. Reneman R.S. aut Hoeks, A.P.G. Hoeks A.P.G. aut Popele, N.M-L. van Popele, van Nicole aut Witteman, J.C.M. Witteman Jacqueline aut Hofman, A. Hofman Albert aut 7005542766 071889256 07101876X 069249733 Erasmus MC: University Medical Center Rotterdam Supporting host sht en English Arteriosclerosis, Thrombosis, and Vascular Biology 1079-5642 1999-01-01 Comparative Study Adult Female Humans Middle aged Research Support, Non-U.S. Gov't Blood Pressure/physiology Cardiovascular Diseases/physiopathology Carotid Artery, Common/*physiology Postmenopause/*physiology Premenopause/*physiology Vasodilation/*physiology Erasmus University Rotterdam oai:repub.eur.nl/res/pub/9058 IR OAIPMH feed (http://repub.eur.nl/oai) 2007-03-12T10:53:30Z 2011-11-21T10:30:32Z http://purl.org/eprint/accessRights/OpenAccess