2013-05-22T06:11:35Z http://repub.eur.nl/oai

oai:repub.eur.nl/res/pub/9064 2012-11-14T12:29:58Z org:9755 org:9746 access:open type:article

urn:NBN:nl:ui:15-1765/9064 2012-11-14T12:29:58 mods http://hdl.handle.net/1765/9064 hdl:1765/9064 urn:NBN:nl:ui:15-1765/9064 Prolonged QT interval predicts cardiac and all-cause mortality in the elderly. The Rotterdam Study text article http://hdl.handle.net/1765/9064 http://repub.eur.nl/res/pub/9064/10099922.pdf application/pdf Filesize: 197 KB born digital AIMS: To examine the association between heart-rate corrected QT prolongation and cardiac and all-cause mortality in the population-based Rotterdam Study among men and women aged 55 years or older and to compare the prognostic value of the QT interval, using different formulas to correct for heart rate. METHODS AND RESULTS: After exclusion of participants with arrhythmias or bundle branch block on the ECG, the study population consisted of 2083 men and 3158 women. The QT interval was computed by the Modular ECG Analysis System (MEANS). Data were analysed using Cox' proportional hazards model. Participants in the highest quartile of the heart-rate corrected QT interval had about a 70% age- and sex-adjusted increased risk for both all-cause mortality (hazard ratio (HR) 1.8; 95% CI:1.3-2.4) and cardiac mortality (HR 1.7; 95% CI:1.0-2.7) compared to those in the lowest quartile. In women, the increased risk associated with prolonged QT for cardiac death was more pronounced than in men. These risk estimates did not change after adjustment for potential confounders, including history of myocardial infarction, hypertension and diabetes mellitus. CONCLUSION: A prolonged heart-rate corrected QT interval is an independent predictor for cardiac and all-cause mortality in older men and women. The risk associated with prolonged QT is hardly affected by the heart-rate correction formula used. Bruyne, M.C. de Bruyne, de Martine aut Hoes, A.W. Hoes Arno aut Kors, J.A. Kors Jan aut Bemmel, J.H. van Bemmel, van Jan aut Grobbee, D.E. Grobbee Diederick aut Hofman, A. Hofman Albert aut 091463637 073383376 071889256 069249733 Erasmus MC: University Medical Center Rotterdam Supporting host sht en English European Heart Journal 0195-668X 1999-02-01 Male Age Distribution Aged Cohort Studies Female Humans Middle aged Sex Distribution *Electrocardiography Netherlands Predictive Value of Tests Proportional Hazards Models Survival Rate Risk Assessment Confidence Intervals *Cause of Death Comorbidity Coronary Disease/epidemiology/*mortality Long QT Syndrome/diagnosis/*epidemiology/physiopathology Erasmus University Rotterdam oai:repub.eur.nl/res/pub/9064 IR OAIPMH feed (http://repub.eur.nl/oai) 2007-03-12T14:03:07Z 2011-11-21T10:30:32Z http://purl.org/eprint/accessRights/OpenAccess