2013-05-26T04:25:11Z http://repub.eur.nl/oai

oai:repub.eur.nl/res/pub/9849 2012-11-14T12:35:31Z org:9825 org:9821 org:9830 org:9802 org:9755 org:9746 access:open type:article

urn:NBN:nl:ui:15-1765/9849 2012-11-14T12:35:31 mods http://hdl.handle.net/1765/9849 hdl:1765/9849 urn:NBN:nl:ui:15-1765/9849 Structure of Campylobacter jejuni lipopolysaccharides determines antiganglioside specificity and clinical features of Guillain-Barré and Miller Fisher patients text article http://hdl.handle.net/1765/9849 http://repub.eur.nl/res/pub/9849/11854201.pdf application/pdf Filesize: 125 KB born digital Ganglioside mimicry in the lipopolysaccharide (LPS) fraction of Campylobacter jejuni isolated from Guillain-Barre syndrome (GBS) and Miller Fisher syndrome (MFS) patients was compared with isolates from patients with an uncomplicated enteritis. The antibody response to C. jejuni LPS and gangliosides in neuropathy patients and controls was compared as well. LPS from GBS and MFS-associated isolates more frequently contained ganglioside-like epitopes compared to control isolates. Almost all neuropathy patients showed a strong antibody response against LPS and multiple gangliosides in contrast to enteritis patients. Isolates from GBS patients more frequently had a GM1-like epitope than isolates from MFS patients. GQ1b-like epitopes were present in all MFS-associated isolates and was associated with anti-GQ1b antibody reactivity and the presence of oculomotor symptoms. These results demonstrate that the expression of ganglioside mimics is a risk factor for the development of post-Campylobacter neuropathy. This study provides additional evidence for the hypothesis that the LPS fraction determines the antiganglioside specificity and clinical features in post-Campylobacter neuropathy patients. Ang, C.W. Ang Wim aut Laman, J.D. Laman Jon aut Willison, H.J. Willison Hugh aut Wagner, E.R. Wagner E.R. aut Endtz, H.P. Endtz Hubert aut Klerk, M.A. de Klerk, de M.A. aut Tio-Gillen, A.P. Tio-Gillen A.P. aut Braak, N.P.W.C.J. van den Braak, van den Nicole aut Jacobs, B.C. Jacobs Bart aut Doorn, P.A. van Doorn, van Pieter aut 212773372 08959469X 10770420X 162621825 075009838 Erasmus MC: University Medical Center Rotterdam Supporting host sht en English Infection and Immunity 0019-9567 2002-01-01 Humans Research Support, Non-U.S. Gov't Molecular Sequence Data Serotyping Bacterial Typing Techniques Gangliosides/*immunology Antibodies, Bacterial/blood Carbohydrate Sequence Campylobacter Infections/complications Campylobacter jejuni/*chemistry/classification/immunology Guillain-Barre Syndrome/*etiology/microbiology Miller Fisher Syndrome/*etiology/microbiology Lipopolysaccharides/*chemistry/immunology Molecular Mimicry Erasmus University Rotterdam oai:repub.eur.nl/res/pub/9849 IR OAIPMH feed (http://repub.eur.nl/oai) 2007-04-25T10:18:49Z 2011-11-23T09:59:13Z http://purl.org/eprint/accessRights/OpenAccess