V. Tikhomirov
http://repub.eur.nl/ppl/5188/
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http://repub.eur.nl/
RePub, Erasmus University RepositoryGenome-wide association study of Tourette's syndrome
http://repub.eur.nl/pub/74298/
Sat, 01 Jun 2013 00:00:01 GMT<div>J.M. Scharf</div><div>D. Yu</div><div>C. Mathews</div><div>M.C. Neale</div><div>S.E. Stewart</div><div>J. Fagerness</div><div>P. Evans</div><div>E. Gamazon</div><div>C.K. Edlund</div><div>S. Service</div><div>V. Tikhomirov</div><div>L. Osiecki</div><div>C. Illmann</div><div>A. Pluzhnikov</div><div>A.I. Konkashbaev</div><div>L.K. Davis</div><div>B. Han</div><div>L.M.A. Crane</div><div>P. Moorjani</div><div>A.T. Crenshaw</div><div>M. Parkin</div><div>V.I. Reus</div><div>T.L. Lowe</div><div>M. Rangel-Lugo</div><div>S. Chouinard</div><div>Y. Dion</div><div>S.L. Girard</div><div>D. Cath</div><div>G.D. Smith</div><div>R.A. King</div><div>T.V. Fernandez</div><div>J.F. Leckman</div><div>K.K. Kidd</div><div>J.R. Kidd</div><div>A.J. Pakstis</div><div>M.W. State</div><div>L.D. Herrera</div><div>R. Romero</div><div>E. Fournier</div><div>P. Sandor</div><div>C.L. Barr</div><div>N. Phan</div><div>V. Gross-Tsur</div><div>F. Benarroch</div><div>M.N. Pollak</div><div>C.L. Budman</div><div>R.D. Bruun</div><div>G. Erenberg</div><div>A.L. Naarden</div><div>P.C. Lee</div><div>N. Weiss</div><div>B. Kremeyer</div><div>G.B. Berrio</div><div>D. Campbell</div><div>J.C. Cardona Silgado</div><div>W.C. Ochoa</div><div>S.C. Mesa Restrepo</div><div>H. Muller</div><div>A.V. Valencia Duarte</div><div>H.N. Lyon</div><div>M.F. Leppert</div><div>J. Morgan</div><div>R. Weiss</div><div>M. Grados</div><div>K. Anderson</div><div>S. Davarya</div><div>H.S. Singer</div><div>J.T. Walkup</div><div>J. Jankovic</div><div>J.A. Tischfield</div><div>M.L. Heiman</div><div>D.L. Gilbert</div><div>P. Hoekstra</div><div>M.M. Robertson</div><div>R. Kurlan</div><div>C. Liu</div><div>J.R. Gibbs</div><div>A. Singleton</div><div>J. Hardy</div><div>E. Strengman</div><div>R.A. Ophoff</div><div>M. Wagner</div><div>R. Moessner</div><div>D. Mirel</div><div>D. Posthuma</div><div>C. Sabatti</div><div>E. Eskin</div><div>G. Conti</div><div>J.A. Knowles</div><div>A. Ruiz-Linares</div><div>G.A. Rouleau</div><div>S. Purcell</div><div>P. Heutink</div><div>B.A. Oostra</div><div>W.M. McMahon</div><div>N.B. Freimer</div><div>N.J. Cox</div><div>D.L. Pauls</div>
Tourette's syndrome (TS) is a developmental disorder that has one of the highest familial recurrence rates among neuropsychiatric diseases with complex inheritance. However, the identification of definitive TS susceptibility genes remains elusive. Here, we report the first genome-wide association study (GWAS) of TS in 1285 cases and 4964 ancestry-matched controls of European ancestry, including two European-derived population isolates, Ashkenazi Jews from North America and Israel and French Canadians from Quebec, Canada. In a primary meta-analysis of GWAS data from these European ancestry samples, no markers achieved a genome-wide threshold of significance (P<5 × 10 -8); the top signal was found in rs7868992 on chromosome 9q32 within COL27A1 (P=1.85 × 10 -6). A secondary analysis including an additional 211 cases and 285 controls from two closely related Latin American population isolates from the Central Valley of Costa Rica and Antioquia, Colombia also identified rs7868992 as the top signal (P=3.6 × 10 -7 for the combined sample of 1496 cases and 5249 controls following imputation with 1000 Genomes data). This study lays the groundwork for the eventual identification of common TS susceptibility variants in larger cohorts and helps to provide a more complete understanding of the full genetic architecture of this disorder.Duality and calculus of convex objects (theory and applications)
http://repub.eur.nl/pub/58825/
Mon, 01 Jan 2007 00:00:01 GMT<div>J. Brinkhuis</div><div>V. Tikhomirov</div>
A new approach to convex calculus is presented, which allows one to treat from a single point of view duality and calculus for various convex objects. This approach is based on the possibility of associating with each convex object (a convex set or a convex function) a certain convex cone without loss of information about the object. From the duality theorem for cones duality theorems for other convex objects are deduced as consequences. The theme 'Duality formulae and the calculus of convex objects' is exhausted (from a certain precisely formulated point of view).A simple view on convex analysis and its applications
http://repub.eur.nl/pub/7024/
Thu, 03 Nov 2005 00:00:01 GMT<div>J. Brinkhuis</div><div>V. Tikhomirov</div>
Our aim is to give a simple view on the basics and applications of convex analysis. The essential feature of this account is the systematic use of the possibility to associate to each convex object---such as a convex set, a convex function or a convex extremal problem--- a cone, without loss of information. The core of convex analysis is the possibility of the dual description of convex objects, geometrical and algebraical, based on the duality of vectorspaces; for each type of convex objects, this property is encoded in an operator of duality, and the name of the game is how to calculate these operators. The core of this paper is a unified presentation, for each type of convex objects, of the duality theorem and the complete list of calculus rules.
Now we enumerate the advantages of the `cone'-approach. It gives a unified and transparent view on the subject. The intricate rules of the convex calculus all flow naturally from one common source. We have included for each rule a precise description of the weakest convenient assumption under which it is valid. This appears to be useful for applications; however, these assumptioons are usually not given. We explain why certain convex objects have to be excluded in the definition of the operators of duality: the collections of associated cones of the target of an operator of duality need not be closed (here `closed' is meant in an algebraic sense). This makes clear that the remedy is to take the closure of the target. As a byproduct of the cone approach, we have found the solution of the open problem of how to use the polar operation to give a dual description of arbitrary convex sets.
The approach given can be extended to the infinite-dimensional case.On the Duality Theory of Convex Objects
http://repub.eur.nl/pub/6848/
Mon, 13 Aug 2001 00:00:01 GMT<div>J. Brinkhuis</div><div>V. Tikhomirov</div>
We consider the classical duality operators for convex objects such as the polar of a convex set containing the origin, the dual norm, the Fenchel-transform of a convex function and the conjugate of a convex cone. We give a new, sharper, unified treatment of the theory of these operators, deriving generalized theorems of Hahn-Banach, Fenchel-Moreau and Dubovitsky-Milyutin for the conjugate of convex cones in not necessarily finite dimensional vector spaces and hence for all the other duality operators of convex objects.