The interrupter technique is a convenient and sensitive technique for studying airway function in subjects who cannot actively participate in (forced) ventilatory function tests. Reference values for preschool children exist but are lacking for children >7 yrs. Reference values were obtained for expiratory interrupter resistance (R(int,e)) in 208 healthy Dutch Caucasian children 3-13 yrs of age. A curvilinear relationship between R(int,e) and height was observed, similar to published airways resistance data measured by plethysmography. No significant differences in cross-sectional trend or level of R(int,e) were observed according to sex. It was found that Z-scores could be used to express individual R(int,e) values and to describe intra- and interindividual differences based on the reference equation: 10logR(int,e)=0.645-0.00668x standing height (cm) kPa x L(-1) x s(-1) and residual SD (0.093 kPa x L(-1) x s(-1)). Expiratory interrupter resistance provides a tool for clinical and epidemiological assessment of airway function in a large age range.

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Keywords Adolescent, Age Factors, Airway Resistance/*physiology, Anthropometry, Child, Child, Preschool, Comparative Study, Female, Humans, Lung Compliance, Male, Probability, Prospective Studies, Reference Values, Respiratory Function Tests/*methods, Respiratory Mechanics/*physiology, Respiratory Physiology, Sensitivity and Specificity
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Merkus, P.J.F.M., Arets, H.G., Joosten, T., Siero, A., Brouha, M., Mijnsbergen, J.Y., … van der Ent, C.K.. (2002). Measurements of interrupter resistance: reference values for children 3-13 yrs of age. The European Respiratory Journal. Retrieved from