Aplastic anaemia: a review
Aplastic anaemia is featured by bone marrow hypocellularity and peripheral pancytopenia and is a potentially fatal disease. In recent years, insight in it pathogenesis has increased. It appears that activated autoreactive T lymphocytes induce apoptosis of haematopoietic stem cells resulting in a hypocellular bone marrow. Nowadays, it can be treated by stem cell transplantation or immunosuppressive therapy. This review focuses on the pathophysiology and treatment of aplastic anaemia.
|Keywords||Anemia, Aplastic/diagnosis/*physiopathology/*therapy, Humans|
Sleijfer, S., & Lugtenburg, P.J.. (2003). Aplastic anaemia: a review. Netherlands Journal of Medicine. Retrieved from http://hdl.handle.net/1765/10206