The overall median survival in glioblastoma multiforme (GBM) patients is less than one year and fewer than 5% of patients survive more than 5 years. The current standard of care for GBM patients involves neurosurgical resection of the tumor followed by radiotherapy with concomitant and adjuvant temozolomide chemotherapy. After initial treatment, all malignant gliomas eventually recur, mostly within a 2-3 cm margin of the original tumor on CT/MRI. The poor prognosis warrants research into new treatment modalities for malignant gliomas. Novel therapeutic approaches in the treatment of GBM include chemotherapy, targeted molecular agents, immunotherapy and virotherapy/gene therapy. Because malignant gliomas only rarely metastasize outside the skull, novel locoregional treatment modalities such as gene therapy are potentially interesting. The aim of this thesis was to identify bottlenecks limiting the efficacy of glioma gene therapy and address some of these bottlenecks in the laboratory.

Additional Metadata
Keywords GBM, gen therapy, gliomas
Promotor Sillevis Smitt, P.A.E. (Peter)
Publisher Erasmus University Rotterdam
Sponsor KWF Kankerbestrijding, Amsterdam, The Netherlands, Revolving Fund from the Erasmus MC Rotterdam
Persistent URL hdl.handle.net/1765/13140
Citation
Nanda, D.. (2008, June 25). Gene Therapy for Gliomas. Erasmus University Rotterdam. Retrieved from http://hdl.handle.net/1765/13140