The use of micro-CT to study bone architecture dynamics noninvasively
High-resolution micro-CT has become a standard tool in the evaluation of bone architecture. It has recently progressed from an invasive tool for bone specimens into an in vivo tool for small animals. The combination of novel sophisticated evaluation methods, such as registration (matching) of sequential scans and computer simulation models will further evolve in vivo micro-CT into an optimal tool for small animal phenotyping and contemporary approaches for drug discovery relating to the skeleton.
|Keywords||accuracy, alendronic acid, bisphosphonic acid derivative, bone density, bone metabolism, bone remodeling, bone strength, bone stress, bone structure, bone turnover, calcitonin, cancellous bone, computer assisted tomography, computer model, computer simulation, drug effect, drug mechanism, histopathology, image reconstruction, in vivo study, non invasive measurement, nonhuman, nuclear magnetic resonance imaging, osteoarthritis, osteoporosis, parathyroid hormone, phenotype, positron emission tomography, process optimization, radiation dose, reliability, review, risedronic acid, selective estrogen receptor modulator, single photon emission computer tomography, structure analysis, three dimensional imaging, trabecular bone|
|Persistent URL||dx.doi.org/10.1016/j.ddtec.2006.06.006, hdl.handle.net/1765/15445|
van der Linden, J.C., Waarsing, J.H., & Weinans, H.H.. (2006). The use of micro-CT to study bone architecture dynamics noninvasively. Drug Discovery Today: Technologies, 3(2), 213–219. doi:10.1016/j.ddtec.2006.06.006