Lymphatic vessels have important roles in fluid homeostasis, fat absorption, inflammation and cancer metastasis and develop in a dynamic process (called lymphangiogenesis) involving budding, migration and proliferation of lymphangioblasts. Using a genetic screen in zebrafish we identify ccbe1 (collagen and calcium-binding EGF domain-1) as indispensible for embryonic lymphangiogenesis. Ccbe1 acts at the same stage of development as Vegfc and is required for lymphangioblast budding and angiogenic sprouting from venous endothelium.

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Keywords angiogenesis, article, calcium binding, collagen, developmental stage, embryo, endothelial cell growth factor, endothelium cell, genetic screening, nonhuman, priority journal, protein domain, vascularization, vasculotropin C, zebra fish
Persistent URL dx.doi.org/10.1038/ng.321, hdl.handle.net/1765/16241
Citation
Hogan, B.M, Bos, F.L, Bussmann, J, Witte, M, Chi, N.C, Duckers, H.J, & Schulte-Merker, S. (2009). Ccbe1 is required for embryonic lymphangiogenesis and venous sprouting. Nature Genetics, 41(4), 396–398. doi:10.1038/ng.321