Ccbe1 is required for embryonic lymphangiogenesis and venous sprouting
Lymphatic vessels have important roles in fluid homeostasis, fat absorption, inflammation and cancer metastasis and develop in a dynamic process (called lymphangiogenesis) involving budding, migration and proliferation of lymphangioblasts. Using a genetic screen in zebrafish we identify ccbe1 (collagen and calcium-binding EGF domain-1) as indispensible for embryonic lymphangiogenesis. Ccbe1 acts at the same stage of development as Vegfc and is required for lymphangioblast budding and angiogenic sprouting from venous endothelium.
|Keywords||angiogenesis, article, calcium binding, collagen, developmental stage, embryo, endothelial cell growth factor, endothelium cell, genetic screening, nonhuman, priority journal, protein domain, vascularization, vasculotropin C, zebra fish|
|Persistent URL||dx.doi.org/10.1038/ng.321, hdl.handle.net/1765/16241|
Hogan, B.M., Bos, F.L., Bussmann, J., Witte, M., Chi, N.C., Duckers, H.J., & Schulte-Merker, S.. (2009). Ccbe1 is required for embryonic lymphangiogenesis and venous sprouting. Nature Genetics, 41(4), 396–398. doi:10.1038/ng.321