(Pro)Renin Uptake and Prorenin Activation in the Cardiovascular System
Traditionally the renin-angiotensin system (RAS) has been viewed as a circulating system. Circulating renin, released by the kidneys, cleaves liver-derived angiotensinogen, which yields the inactive decapeptide angiotensin I (Ang (1-10) or Ang I) (Figure 1). Ang I is subsequently converted into an octapeptide, angiotensin II (Ang (1-8) or Ang II), by angiotensin-converting enzyme (ACE), an enzyme that is either located at the huninal side of the endothelium or circulating freely in plasma. Ang II is rapidly metabolized by so-called angiotensinases.
|Publisher||Erasmus MC: University Medical Center Rotterdam|
|Promotor||Saxena, P.R. (Pramod Ranjan) , Schalekamp, M.A.D.H. (Maarten)|
|Sponsor||Netherlands Heart Foundation, Dr Saal van Zwanenberg Foundation|
|Keywords||cardiology, cardiovascular system, renin-angiotensin|
van Kesteren, C.A.M.. (1998, December 17). (Pro)Renin Uptake and Prorenin Activation in the Cardiovascular System. Erasmus MC: University Medical Center Rotterdam. Retrieved from http://hdl.handle.net/1765/17193