This article reviews the microbiological diagnostic tests that are currently available for the detection of M pneumoniae, C pneumoniae, and Legionella spp; their clinical performance; and their future in the clinical microbiology laboratory. When implementing a strategy, a balance between performance criteria (sensitivity, specificity) and convenience criteria (clinical utility, turnaround time, and costs) will have to be defined. In the end, this should result in the optimization of clinical patient management.

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Keywords Chlamydophila pneumoniae, Diagnostic tests, Legionella pneumophila, Mycoplasma pneumonia, Mycoplasma pneumoniae, analytic method, antigen detection, bacterial antigen, bacterium culture, bacterium detection, chlamydial pneumonia, community acquired pneumonia, diagnostic accuracy, diagnostic value, disease severity, enzyme linked immunosorbent assay, gold standard, human, intermethod comparison, legionnaire disease, multiplex ligation dependent probe amplification, nonhuman, nucleic acid amplification, nucleotide sequence, pertussis, real time polymerase chain reaction, review, sensitivity and specificity, serodiagnosis, strand displacement amplification, tularemia, turnaround time, urinalysis
Persistent URL dx.doi.org/10.1016/j.idc.2009.10.013, hdl.handle.net/1765/19432
Citation
te Witt, R, van Leeuwen, W.B, & van Belkum, A.F. (2010). Specific Diagnostic Tests for Atypical Respiratory Tract Pathogens. Infectious Disease Clinics of North America, 24(1), 229–248. doi:10.1016/j.idc.2009.10.013