Glycemic control and long-acting insulin analog utilization in patients with type 2 diabetes
Introduction: The objective was to compare glycemic control, insulin utilization, and body weight in patients with type 2 diabetes (T2D) initiated on insulin detemir (IDet) or insulin glargine (IGlar) in a real-life setting in the Netherlands. Methods: Insulin-naïve patients with T2D, starting treatment with IDet or IGlar between January 1, 2004 and June 30, 2008, were selected from the PHARMO data network. Glycemic control (hemoglobin A1c [HbA1c]), target rates (HbA1c <7%), daily insulin dose, and weight gain were analyzed comparing IDet and IGlar for patients with available HbA1c levels both at baseline and at 1-year follow-up. Analysis of all eligible patients (AEP) and a subgroup of patients without treatment changes (WOTC) in the follow-up period were adjusted for patient characteristics, propensity scores, and baseline HbA1c. Results: A total of 127 IDet users and 292 IGlar users were included in the WOTC analyses. The mean HbA1c dropped from 8.4%-8.6% at baseline to 7.4% after 1 year. Patients at HbA1c goal increased from 9% at baseline to 32% for IDet and 11% to 35% for IGlar, which was not significantly different (OR 0.75, 95% CI 0.46, 1.24). Weight gain (n=90) was less among IDet users (+0.4kg) than among IGlar users (+1.1kg), albeit not significant. The AEP analysis (252 IDet + 468 IGlar users) showed similar results with 33%-36% at goal (OR 0.81, 95% CI 0.57, 1.16), and median daily insulin doses of 25 IU/day (P=0.70). Conclusion: There was no significant difference between users of IDet and IGlar with respect to glycemic control and insulin dose in a real-life setting. The low proportion of patients on target at baseline may indicate that insulin therapy is initiated too late. Moreover, the observation that one-third of the patients reached HbA1c target at follow-up may indicate that basal insulin analogs are not titrated intensively enough.
|Keywords||HbA1c, dose, glycemic control, insulin detemir, insulin glargine, retrospective cohort study, type 2 diabetes, utilization|
|Persistent URL||dx.doi.org/10.1007/s12325-010-0020-y, hdl.handle.net/1765/19709|
|Journal||Advances in Therapy: the international journal of drug, device and diagnostic research|
Heintjes, E.M, Thomsen, T.L, Penning-Van Beest, F.J.A, Christensen, T.E, & Herings, R.M.C. (2010). Glycemic control and long-acting insulin analog utilization in patients with type 2 diabetes. Advances in Therapy: the international journal of drug, device and diagnostic research, 27(4), 211–222. doi:10.1007/s12325-010-0020-y