Case ReportA Case Series of Proton Pump Inhibitor–Induced Hypomagnesemia
Section snippets
Case Reports
The 4 cases are described next and in Table 1 (showing all laboratory values).
Discussion
This series of 4 patients with PPI-induced hypomagnesemia, hypocalcemia, and hypokalemia adds several new and clinically relevant points.
According to the scale of Naranjo et al,7 the likelihood that the PPIs caused hypomagnesemia was “probable” (Table 1). All cases had additional pathologic states that could have contributed to the degree of hypomagnesemia (partial colectomy,8 diabetes mellitus,9 intestinal lymphangiectasia,10 and ion-exchange resin). However, it seems very unlikely that these
Acknowledgements
The authors thank Drs T. van Gelder and R.H. van Schaik for pharmacogenetic analysis, Dr M.N. Boomgaard for referring case 1, and Dr F.P. van der Dijs for help with retrieving the laboratory values for case 3.
Support: None.
Financial Disclosure: The authors declare that they have no relevant financial interests.
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Originally published online as doi:10.1053/j.ajkd.2009.11.019 on May 17, 2010.