Original articleIncidence of Glaucomatous Visual Field Loss: A Ten-Year Follow-up from the Rotterdam Study
Section snippets
Study Population
The present study is part of the Rotterdam Study, a prospective population-based cohort study aimed at studying the occurrence of and risk factors for chronic diseases in the elderly. Its objectives, methods, and major findings have been described.22 The medical ethics committee of the Erasmus University approved the study protocol, and all participants provided written informed consent in accordance with the Declaration of Helsinki. After the baseline examinations between 1990 and 1993,
Results
The mean time was 6.5 years (range 5.0–9.4 years) between baseline and the first follow-up and 11.1 years (range 7.9–13.9 years) between baseline and the second follow-up. Figure 1 shows the course over time of the 6630 participants at risk of iGVFL; 3939 of 6630 participants (59%) completed at least 1 follow-up examination; 2571 participants (39%) completed both follow-up examinations. The mean follow-up time was 9.8 years (range 5.0–13.9 years).
Table 1 shows the baseline characteristics of
Discussion
Our longitudinal study with long-term follow-up shows that the 10-year risk of GVFL in a general elderly white population is highly dependent on age. The 10-year risk increases from approximately 2% in the sixth decade to approximately 6% in the highest age category. The incidence is significantly associated with higher baseline IOP, high myopia, male gender, a positive family history of glaucoma, and GON at baseline.
Open-angle glaucoma was defined in the Rotterdam Study, and in most other
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2020, OphthalmologyCitation Excerpt :Also, we were not able to confirm the association of visual field deterioration with pseudoexfoliation8 because the latter was rare in the UKGTS participants (0.5%) and therefore was not included in the analysis. Older age is an established risk factor for the onset of glaucoma.24–27 Also, older age has been associated strongly with the progression of OAG in the Early Manifest Glaucoma Trial (EMGT),8 the Advanced Glaucoma Intervention Study (AGIS),9 and the Collaborative Initial Glaucoma Treatment Study (CIGTS).10
Manuscript no. 2009-720.
Financial Disclosure(s): The author(s) have no proprietary or commercial interest in any materials discussed in this article.
Financial support: The Netherlands Organization for Health Research and Development (ZonMw) grant 2200.0035, The Hague; Lijf en Leven, Krimpen a/d Lek; MD Fonds, Utrecht. Oogfonds Nederland, Utrecht; MD Fonds, Utrecht; Stichting Nederlands Oogheelkundig Onderzoek, Nijmegen/Rotterdam; Swart van Essen, Rotterdam; Netherlands Organisation for Scientific Research, The Hague; Bevordering van Volkskracht, Rotterdam; Blindenhulp, The Hague; Landelijke Stichting voor Blinden en Slechtzienden, Utrecht; Rotterdamse Vereniging voor Blindenbelangen, Rotterdam; OOG, The Hague; Algemene Nederlandse Vereniging ter Voorkoming van Blindheid, Doorn; Laméris Ootech BV, Nieuwegein; Medical Workshop BV, Groningen; Topcon Europe BV, Capelle aan de IJssel, all in the Netherlands, and Heidelberg Engineering, Dossenheim, Germany. The sponsors or funding organizations had no role in the design, conduct, analysis or publication of this research.
This population-based prospective study estimates the 10-year incidence of glaucomatous visual field loss in a general elderly white population to be approximately 3%.