Objective: The purpose of this study was to compare clinical outcome and health related quality of life (HRQOL) 5 years after uterine artery embolization (UAE) or hysterectomy in the treatment of menorrhagia caused by uterine fibroids. Study Design: Patients with symptomatic uterine fibroids who were eligible for hysterectomy were assigned randomly 1:1 to hysterectomy or UAE. Endpoints after 5 years were reintervention rates, menorrhagia, and HRQOL measures that were assessed by validated questionnaires. Results: Patients were assigned randomly to UAE (n = 88) or hysterectomy (n = 89). Five years after treatment 23 of 81 UAE patients (28.4%) had undergone a hysterectomy because of insufficient improvement of complaints (24.7% after successful UAE). HRQOL measures improved significantly and remained stable until the 5-year follow-up evaluation, with no differences between the groups. UAE had a positive effect both on urinary and defecation function. Conclusion: UAE is a well-established alternative to hysterectomy about which patients should be counseled.

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Keywords abdominal hysterectomy, adult, article, blood transfusion, controlled study, defecation, female, fibroid tumor, follow up, hormonal therapy, human, hysterectomy, intrauterine contraceptive device, iron therapy, levonorgestrel, major clinical study, menorrhagia, nonsteroid antiinflammatory agent, oral contraception, oral contraceptive agent, patient satisfaction, priority journal, quality of life, questionnaire, tranexamic acid, urinary tract function, uterine artery embolization, uterus myoma, vaginal hysterectomy
Persistent URL dx.doi.org/10.1016/j.ajog.2010.01.049, hdl.handle.net/1765/21162
van der Kooij, S.M., Hehenkamp, W.J.K., Volkers, N.A., Birnie, E., Ankum, W.M., & Reekers, J.A.. (2010). Uterine artery embolization vs hysterectomy in the treatment of symptomatic uterine fibroids: 5-Year outcome from the randomized EMMY trial. American Journal of Obstetrics & Gynecology, 203(2), 105–105. doi:10.1016/j.ajog.2010.01.049