Regulation and modulation of the plasma fibrinogen level
Fibrinogen is a soluble plasma glycoprotein that, under normal circumstances, is present in human plasma at a concentration of 2-4 mg/ml (6-12 I'M). The plasma half-life is 3-4 days in humans and about 10-25 % of the total body fibrinogen is extravascularl. Fibrinogen is composed of two sets of three polypeptide chains (AOI, 86 . and 'Y) that are interconnected by disulphide bridges . The aminoterminal segments of all six chains form a central domain from which the AOI and 86 chains protrude. These aminotermini are the target of thrombin and small peptides (FPA and FP8) can be cleaved off.
|Publisher||Erasmus MC: University Medical Center Rotterdam|
|Promotor||Kluft, C. (Cornelius) , Wilson, J.H.P. (Paul)|
|Sponsor||Netherlands Heart Foundation, Sanofi-Winthrop V.O.F., TNO|
|Keywords||fibrinogen, hematology, plasma|
de Maat, M.P.M.. (1995, March 15). Regulation and modulation of the plasma fibrinogen level. Erasmus MC: University Medical Center Rotterdam. Retrieved from http://hdl.handle.net/1765/21470