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Increased risk of adenomas in individuals with a family history of colorectal cancer: results of a meta-analysis

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Abstract

Objective

It is unclear to what extent the increased risk of colorectal cancer in individuals with a family history of colorectal cancer and no known genetic disorders is associated with a higher adenoma prevalence. Our aim is to estimate the relative difference in adenoma prevalence and its age-pattern in individuals with a family history of colorectal cancer compared to those without.

Methods

We performed a literature search to identify colonoscopy studies reporting the adenoma prevalence by age. Using multilevel logistic regression, we examined how the adenoma prevalence by age differed between individuals with and without a family history of colorectal cancer. We excluded members of families with a known genetic disorder.

Results

Thirteen colonoscopy studies were identified. The adenoma prevalence was significantly higher in individuals with a family history than in those without (OR 1.7, 95% CI 1.4–3.5). The adenoma prevalence increased with age (OR per year of age 1.06, 95% CI 1.05–1.07). The age trend did not differ significantly between the two groups.

Conclusion

Individuals with a family history of colorectal cancer have a considerably higher prevalence of adenomas compared to individuals without a family history. This is consistent with their increased risk of colorectal cancer.

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References

  1. Baglietto L, Jenkins MA, Severi G et al (2006) Measures of familial aggregation depend on definition of family history: meta-analysis for colorectal cancer. J Clin Epidemiol 59:114–124

    Article  PubMed  Google Scholar 

  2. Butterworth AS, Higgins JP, Pharoah P (2006) Relative and absolute risk of colorectal cancer for individuals with a family history: a meta-analysis. Eur J Cancer 42:216–227

    Article  PubMed  Google Scholar 

  3. Johns LE, Houlston RS (2001) A systematic review and meta-analysis of familial colorectal cancer risk. Am J Gastroenterol 96:2992–3003

    Article  CAS  PubMed  Google Scholar 

  4. Morson BC (1984) The evolution of colorectal carcinoma. Clin Radiol 35:425–431

    Article  CAS  PubMed  Google Scholar 

  5. Jasperson KW, Tuohy TM, Neklason DW, Burt RW (2010) Hereditary and familial colon cancer. Gastroenterology 138:2044–2058

    Article  CAS  PubMed  Google Scholar 

  6. de Jong AE, Vasen HF (2006) The frequency of a positive family history for colorectal cancer: a population-based study in the Netherlands. Neth J Med 64:367–370

    PubMed  Google Scholar 

  7. Mitchell RJ, Campbell H, Farrington SM, Brewster DH, Porteous ME, Dunlop MG (2005) Prevalence of family history of colorectal cancer in the general population. Br J Surg 92:1161–1164

    Article  CAS  PubMed  Google Scholar 

  8. Bazzoli F, Fossi S, Sottili S et al (1995) The risk of adenomatous polyps in asymptomatic first-degree relatives of persons with colon cancer. Gastroenterology 109:783–788

    Article  CAS  PubMed  Google Scholar 

  9. Bonelli L, Martines H, Conio M, Bruzzi P, Aste H (1988) Family history of colorectal cancer as a risk factor for benign and malignant tumours of the large bowel. A case-control study. Int J Cancer 41:513–517

    Article  CAS  PubMed  Google Scholar 

  10. Boutron MC, Faivre J, Quipourt V, Senesse P, Michiels C (1995) Family history of colorectal tumours and implications for the adenoma-carcinoma sequence: a case control study. Gut 37:830–834

    Article  CAS  PubMed  Google Scholar 

  11. Pariente A, Milan C, Lafon J, Faivre J (1998) Colonoscopic screening in first-degree relatives of patients with ‘sporadic’ colorectal cancer: a case-control study. The Association Nationale des Gastroenterologues des Hopitaux and Registre Bourguignon des Cancers Digestifs (INSERM CRI 9505). Gastroenterology 115:7–12

    Article  CAS  PubMed  Google Scholar 

  12. Vasen HF, Watson P, Mecklin JP, Lynch HT (1999) New clinical criteria for hereditary nonpolyposis colorectal cancer (HNPCC, Lynch syndrome) proposed by the international collaborative group on HNPCC. Gastroenterology 116:1453–1456

    Article  CAS  PubMed  Google Scholar 

  13. Moher D, Liberati A, Tetzlaff J, Altman DG, Group P (2009) Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. J Clin Epidemiol 62:1006–1012

    Article  PubMed  Google Scholar 

  14. Dove-Edwin I, Sasieni P, Adams J, Thomas HJ (2005) Prevention of colorectal cancer by colonoscopic surveillance in individuals with a family history of colorectal cancer: 16 year, prospective, follow-up study. Bmj 331:1047

    Article  PubMed  Google Scholar 

  15. Dowling DJ, St John DJ, Macrae FA, Hopper JL (2000) Yield from colonoscopic screening in people with a strong family history of common colorectal cancer. J Gastroenterol Hepatol 15:939–944

    Article  CAS  PubMed  Google Scholar 

  16. Grossman S, Milos ML (1988) Colonoscopic screening of persons with suspected risk factors for colon cancer. I. Family history. Gastroenterology 94:395–400

    CAS  PubMed  Google Scholar 

  17. Guillem JG, Forde KA, Treat MR, Neugut AI, O’Toole KM, Diamond BE (1992) Colonoscopic screening for neoplasms in asymptomatic first-degree relatives of colon cancer patients. A controlled, prospective study. Dis Colon Rectum 35:523–529

    Article  CAS  PubMed  Google Scholar 

  18. Hunt LM, Rooney PS, Hardcastle JD, Armitage NC (1998) Endoscopic screening of relatives of patients with colorectal cancer. Gut 42:71–75

    Article  CAS  PubMed  Google Scholar 

  19. Johnson DA, Gurney MS, Volpe RJ et al (1990) A prospective study of the prevalence of colonic neoplasms in asymptomatic patients with an age-related risk. Am J Gastroenterol 85:969–974

    CAS  PubMed  Google Scholar 

  20. Regula J, Rupinski M, Kraszewska E et al (2006) Colonoscopy in colorectal-cancer screening for detection of advanced neoplasia. N Engl J Med 355:1863–1872

    Article  CAS  PubMed  Google Scholar 

  21. Rundle AG, Lebwohl B, Vogel R, Levine S, Neugut AI (2008) Colonoscopic screening in average-risk individuals ages 40 to 49 vs. 50 to 59 years. Gastroenterology 134:1311–1315

    Article  PubMed  Google Scholar 

  22. Sauar J, Hoff G, Hausken T, Bjorkheim A, Foerster A, Mowinckel P (1992) Colonoscopic screening examination of relatives of patients with colorectal cancer. II. Relations between tumour characteristics and the presence of polyps. Scand J Gastroenterol 27:667–672

    Article  CAS  PubMed  Google Scholar 

  23. Soon MS, Soon A, Lin TY, Lin OS (2008) Distribution of colon neoplasia in Chinese patients: implications for endoscopic screening strategies. Eur J Gastroenterol Hepatol 20:642–647

    Article  PubMed  Google Scholar 

  24. Tung SY, Wu CS (2000) Risk factors for colorectal adenomas among immediate family members of patients with colorectal cancer in Taiwan: a case-control study. Am J Gastroenterol 95:3624–3628

    Article  CAS  PubMed  Google Scholar 

  25. Wu CS, Tung SY, Chen PC, Kuo YC (1995) The role of colonoscopy in screening persons with family history of colorectal cancer. J Gastroenterol Hepatol 10:319–323

    Article  CAS  PubMed  Google Scholar 

  26. Syrigos KN, Charalampopoulos A, Ho JL, Zbar A, Murday VA, Leicester RJ (2002) Colonoscopy in asymptomatic individuals with a family history of colorectal cancer. Ann Surg Oncol 9:439–443

    Article  CAS  PubMed  Google Scholar 

  27. Soon MS, Kozarek RA, Ayub K, Soon A, Lin TY, Lin OS (2005) Screening colonoscopy in Chinese and western patients: a comparative study. Am J Gastroenterol 100:2749–2755

    Article  PubMed  Google Scholar 

  28. Chung SJ, Kim YS, Yang SY et al (2010) Prevalence and risk of colorectal adenoma in asymptomatic Koreans aged 40–49 years undergoing screening colonoscopy. J Gastroenterol Hepatol 25:519–525

    Article  PubMed  Google Scholar 

  29. Kim DH, Lee SY, Choi KS et al (2007) The usefulness of colonoscopy as a screening test for detecting colorectal polyps. Hepatogastroenterology 54:2240–2242

    PubMed  Google Scholar 

  30. Kim KS, Moon HJ, Choi CH et al (2010) The frequency and risk factors of colorectal adenoma in health-check-up subjects in South Korea: relationship to abdominal obesity and age. Gut Liver 4:36–42

    Article  CAS  PubMed  Google Scholar 

  31. Bokemeyer B, Bock H, Huppe D et al (2009) Screening colonoscopy for colorectal cancer prevention: results from a German online registry on 2,69,000 cases. Eur J Gastroenterol Hepatol 21:650–655

    Article  PubMed  Google Scholar 

  32. Kerber RA, Slattery ML (1997) Comparison of self-reported and database-linked family history of cancer data in a case-control study. Am J Epidemiol 146:244–248

    CAS  PubMed  Google Scholar 

  33. Mitchell RJ, Brewster D, Campbell H et al (2004) Accuracy of reporting of family history of colorectal cancer. Gut 53:291–295

    Article  CAS  PubMed  Google Scholar 

  34. Wark PA, Wu K, van ‘t Veer P, Fuchs CF, Giovannucci EL (2009) Family history of colorectal cancer: a determinant of advanced adenoma stage or adenoma multiplicity? Int J Cancer 125:413–420

    Article  CAS  PubMed  Google Scholar 

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Acknowledgments

This research was funded by National Cancer Institute and National Human Genome Research Institute (jointly) 5 R01 CA114794

Author information

Authors and Affiliations

  1. Department of Public Health, Erasmus MC, University Medical Center Rotterdam, P.O. Box 2040, 3000 CA, Rotterdam, The Netherlands

    Janneke A. Wilschut, J. Dik F. Habbema, Rob Boer, Caspar W. N. Looman & Marjolein van Ballegooijen

  2. Fred Hutchinson Cancer Research Center, Seattle, WA, USA

    Scott D. Ramsey

  3. University of Washington, Seattle, WA, USA

    Scott D. Ramsey

Authors
  1. Janneke A. Wilschut
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  2. J. Dik F. Habbema
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  3. Scott D. Ramsey
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  4. Rob Boer
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  5. Caspar W. N. Looman
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  6. Marjolein van Ballegooijen
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Corresponding author

Correspondence to Janneke A. Wilschut.

Appendices

Appendix 1: Search strategy Pubmed

  1. 1.

    Age [tw]

  2. 2.

    Polyp [tw]

  3. 3.

    Polyps [tw]

  4. 4.

    Adenoma [mesh]

  5. 5.

    Adenom*[tw]

  6. 6.

    2 or 3 or 4 or 5

  7. 7.

    Colon [tw]

  8. 8.

    Colonic [tw]

  9. 9.

    Colorect*[tw]

  10. 10.

    Rectum [tw]

  11. 11.

    Rectal [tw]

  12. 12.

    7 or 8 or 9 or 10 or 11

  13. 13.

    Prevalence [tw]

  14. 14.

    Risk [mesh]

  15. 15.

    Risk [tw]

  16. 16.

    13 or 14 or 15

  17. 17.

    Colonoscopy [mesh]

  18. 18.

    Colonoscopy [tw]

  19. 19.

    19 17 or 18

  20. 20.

    1 and 6 and 12 and 16 and 19

Appendix 2

See Table 3.

Table 3 Estimated adenoma prevalence by age and risk group based on three studies with high- and low-risk groups
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Wilschut, J.A., Habbema, J.D.F., Ramsey, S.D. et al. Increased risk of adenomas in individuals with a family history of colorectal cancer: results of a meta-analysis. Cancer Causes Control 21, 2287–2293 (2010). https://doi.org/10.1007/s10552-010-9654-y

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  • DOI: https://doi.org/10.1007/s10552-010-9654-y

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