Maternal and fetal haemodynamic effects of nifedipine in normotensive pregnant women
While nifedipine is commonly used for tocolysis, the controversy on its safety remains. So far, the haemodynamic effects on maternal and fetal circulations have not been well documented. Fifteen normotensive women who received 20 mg nifedipine were included in this prospective observational study. The maternal and fetal haemodynamic effects were analysed using maternal echocardiography and fetal Doppler ultrasonography. Nifedipine induced a significant afterload reduction in all women. It triggered a compensatory increase in cardiac output, which maintained blood pressure. These maternal changes had no influence on the uteroplacental and fetal circulations.
|Keywords||Cardiac output, Doppler echography, adult, article, blood pressure, echocardiography, female, fetus circulation, haemodynamics, heart afterload, heart output, hemodynamics, human, human experiment, nifedipine, normal human, observational study, placenta circulation, pregnancy, priority journal, tocolysis, total vascular resistance|
|Persistent URL||dx.doi.org/10.1111/j.1471-0528.2010.02794.x, hdl.handle.net/1765/23161|
Cornette, J., Duvekot, J.J., Roos-Hesselink, J.W., Hop, W.C.J., & Steegers, E.A.P.. (2011). Maternal and fetal haemodynamic effects of nifedipine in normotensive pregnant women. BJOG: An International Journal of Obstetrics and Gynaecology, 118(4), 510–515. doi:10.1111/j.1471-0528.2010.02794.x