First trimester umbilical cord and vitelline duct measurements using virtual reality
Background: The umbilical cord and vitelline duct are of vital importance to the fetus, but they are rarely the subject of first trimester two-dimensional (2D) ultrasound evaluation due to the complexity of their shape and morphology. Virtual reality (VR) allows efficient visualisation and measurement of complex structures like the umbilical cord and vitelline duct. Aim: To measure normal first trimester human growth of the umbilical cord length (UCL) and vitelline duct length (VDL) using a VR system; and to correlate both measurements with the gestational age (GA) and crown-rump length (CRL) and the VDL with the yolk sac volume (YSV). Study design: Prospective cohort study. Serial three-dimensional (3D) ultrasound measurements were performed from six to 14 weeks GA, resulting in 125 3D volumes. These volumes were analysed using an I-Space VR system. Subjects: Thirty-two healthy pregnant women with an ongoing, normal pregnancy. Outcome measures: The UCL, VDL, YSV and other related structures were measured. Results: The UCL, measurable in 55% of cases, was positively correlated to advancing GA and CRL (p<0.001). The VDL could be measured in 42% of cases and showed a positive relationship with GA and CRL (p<0.001). There was a significant (p<0.001) relationship between YSV and VDL. Conclusions: The present study, facilitated by a VR system, is the first to provide an in-vivo longitudinal description of normal first trimester growth of the human umbilical cord and vitelline duct. Further studies will reveal whether these parameters can be used in detection of abnormal fetal development.
|Keywords||First trimester, Three-dimensional ultrasound, Umbilical cord, Virtual reality, Vitelline duct, adult, article, birth weight, body mass, cohort analysis, correlation analysis, crown rump length, echography, embryo (anatomy), female, fertilization in vitro, fetus development, fetus growth, first trimester pregnancy, gestational age, human, intracytoplasmic sperm injection, intrauterine insemination, maternal age, normal human, pregnant woman, prospective study, three dimensional imaging, umbilical cord, virtual reality, yolk sac, yolk sac volume|
|Persistent URL||dx.doi.org/10.1016/j.earlhumdev.2010.11.002, hdl.handle.net/1765/23528|
Rousian, M., Verwoerd-Dikkeboom, C.M., Koning, A.H.J., Hop, W.C.J., van der Spek, P.J., Steegers, E.A.P., & Exalto, N.. (2011). First trimester umbilical cord and vitelline duct measurements using virtual reality. Early Human Development, 87(2), 77–82. doi:10.1016/j.earlhumdev.2010.11.002