As the possibilities in the treatment of cancer continue to evolve, its early detection and correct diagnosis are becoming increasingly important. Froum the early detection of cancer to the guidance of oncosurgical procedures new sensitive in vivo diagnostic tools are much needed. Many studies report the Raman spectroscopic detection of malignant and premalignanl tissues in different sites of the body with high sensitivities. The great appeal of this technique lies in its potential for in vivo clinical implementation. We present an overview of the in vitro and in vivo work on the oncological application of Raman spectroscopy and discuss its potential as a new tool in the clinico-oncological practice. Opportunities for integration of Raman spectroscopy in oncological cure and care as a real-time guidance tool during diagnostic (i.e. biopsy) and therapeutic (surgical resection) modalities as well as technical shortcomings are discussed from a clinicians point of view. Hut lire Rinnan application lor real-time tumor-border

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Keywords Cancer, Clinical application, Oncology, Pathology, Review, Tissue classification
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Journal Journal of Biophotonics
Nijssen, A, Koljenovic, S, Bakker Schut, T.C, Caspers, P.J, & Puppels, G.J. (2009). Towards oncological application of Raman spectroscopy. Journal of Biophotonics, 2(1-2), 29–36. doi:10.1002/jbio.200810055