Molecular aspects of Moraxella catarrhalis pathogenesis
Our understanding of the factors facilitating M. catarrhalis pathogenesis is far from complete. However, it has already been shown that a complex, multifactorial interaction, involving a wide range of bacterium- and host-specific macromolecules, takes place between M. catarrhalis and its human host. Currently known virulence factors include OMPs, LOS, and metabolic pathways, which are involved in adhesion, invasion, biofilm formation, modulation of the host immune system, and acquisition of nutrients.
|Persistent URL||dx.doi.org/10.1128/MMBR.00007-09, hdl.handle.net/1765/27207|
|Journal||Microbiology and Molecular Biology Reviews|
|Grant||This work was funded by the European Commission 7th Framework Programme; grant id fp7/222983 - A comprehensive dissection of pneumococcal-host interactions (PNEUMOPATH)|
de Vries, S.P.W, Bootsma, H.J, Hays, J.P, & Hermans, P.W.M. (2009). Molecular aspects of Moraxella catarrhalis pathogenesis. Microbiology and Molecular Biology Reviews, 73(3), 389–406. doi:10.1128/MMBR.00007-09