Molecular Cell
Volume 38, Issue 5, 11 June 2010, Pages 637-648
ArticleA Ubiquitin-Binding Domain in Cockayne Syndrome B Required for Transcription-Coupled Nucleotide Excision Repair
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open access
Graphical Abstract
Highlights
► Cockayne syndrome B protein harbors a carboxy-terminal ubiquitin-binding domain (UBD) ► UBD deletion (CSBdel) gives rise to the phenotypes typical of cells lacking CSB activity ► CSBdel becomes immobilized at DNA lesions and no longer supports transcription reactiviation ► CSBdel supports assembly of repair complexes, but these are incapable of damage incision
DNA
PROTEINS
Cited by (0)
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These authors contributed equally to this work
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Present address: Department of Cancer Biology, IPBS-CNRS UMR 5089, 205 route de Narbonne 31077, Toulouse Cedex 04, France
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Present address: Biomedical Sciences Research Center Alexander Fleming, 16672 Vari, Greece
Copyright © 2010 Elsevier Inc.