The prevalence and molecular characteristics of isolates from 173 immunocompetent patients with herpetic keratitis (HK) whowere infected with acyclovir (ACV)-resistant(ACVR) corneal herpes simplex virus (HSV)-1 was determined. Isolates from 11 (6.4%) of the patients were ACVR, and 9 of these 11 patients were refractory to therapy with ACV; the ACVRisolates from 5 and 1 of these 9 patients were cross-resistant to gancyclovir and to both gancyclovir and foscarnet, respectively. Of the 11 ACVRisolates, 10 had, in the thymidine kinase gene, mutations that presumably conferred the ACVRphenotype. These data demonstrate a relatively high prevalence of corneal HSV-1 ACVRisolates in patients with HK, which emphasizes the need to monitor for ACV susceptibility in patients with HK who are refractory to therapy with ACV.

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Persistent URL dx.doi.org/10.1086/590668, hdl.handle.net/1765/29144
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Duan, R., de Vries, R.D., Osterhaus, A.D.M.E., Remeijer, L., & Verjans, G.M.G.M.. (2008). Acyclovir-resistant corneal HSV-1 isolates from patients with herpetic keratitis. The Journal of Infectious Diseases, 198(5), 659–663. doi:10.1086/590668