Objective: To assess long-term health status in patients who survived meningococcal septic shock in childhood. Design: Medical and psychological follow-up of a cross-sectional cohort. Setting: Pediatric intensive care unit (PICU) of a tertiary care university hospital. Participants: All consecutive patients with septic shock and purpura who required intensive care between 1988 and 2001. Intervention: Patients and their parents were invited to our follow-up clinic 4 to 16 years after PICU discharge. Outcome Measures: Health status was assessed with a standard medical interview, physical examination, renal function test, and the Health Utilities Index Mark 2 (HUI2) and 3 (HUI3). Results: One hundred twenty patients (response rate 71%) participated in the follow-up (median age at PICU admission, 3.1 years; median follow-up interval, 9.8 years; median age at follow-up, 14.5 years). Thirty-five percent of patients had 1 or more of the following neurological impairments: severe mental retardation with epilepsy (3%), hearing loss (2%), chronic headache (28%), and focal neurological signs (6%), like paresis of 1 arm. One of the 16 patients with septic shock-associated acute renal failure at PICU admission showed signs of mild chronic renal failure (glomerular filtration rate, 62 mL/min/1.73m2; proteinuria; and hypertension). Scores were significantly lower on nearly all HUI2 and HUI3 attributes compared with Dutch population data, indicating poorer health in these patients. Conclusions: In patients who survived meningococcal septic shock in childhood, one-third showed long-term neurological impairments, ranging from mild to severe and irreversible. Patients reported poorer general health as measured by HUI2 and HUI3.

Additional Metadata
Persistent URL dx.doi.org/10.1001/archpedi.162.11.1036, hdl.handle.net/1765/32373
Citation
Buysse, C.M.P, Raat, H, Hazelzet, J.A, Hulst, J.M, Cransberg, K, Hop, W.C.J, … Joosten, K.F.M. (2008). Long-term health status in childhood survivors of meningococcal septic shock. Archives of Pediatrics & Adolescent Medicine, 162(11), 1036–1041. doi:10.1001/archpedi.162.11.1036