In this issue of the Journal, Zhang et al. (Am J Epidemiol. 2011;174(4):403-411) make a substantial contribution to research in the area of hormonal influences on cardiac repolarization by demonstrating an inverse association between testosterone levels and the Bazett's adjusted QT interval (QTc) and RR-adjusted QT interval in men but not in postmenopausal women. They suggest that testosterone levels might explain the difference in QTc-interval duration between men and women and could contribute to population variability in QTc-interval duration among men. In this commentary, the gender difference and the role of testosterone in human cardiac repolarization are addressed. In addition, the gender differences in the congenital long-QT syndrome, drug-induced ventricular arrhythmias, and sudden cardiac death are discussed.

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Keywords Gonadal steroid hormones, long QT syndrome, testosterone
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Journal American Journal of Epidemiology
van Noord, C, Rodenburg, E.M, & Stricker, B.H.Ch. (2011). Invited commentary: Sex-steroid hormones and qt-interval duration. American Journal of Epidemiology, 174(4), 412–415. doi:10.1093/aje/kwr170