The microbiologic etiology of severe pneumonia in hospitalized patients is rarely known in sub-Saharan Africa. Through a comprehensive diagnostic work-up, we aimed to identify the causative agent in severely ill patients with a clinical picture of pneumonia admitted to a high-dependency unit. A final diagnosis was made and categorized as confirmed or probable by using predefined criteria. Fifty-one patients were recruited (45% females), with a mean age of 35 years (range = 17-88 years), of whom 11(22%) died. Forty-eight (94%) of the patients were seropositive for human immunodeficiency virus; 14 (29%) of these patients were receiving antiretroviral treatment. Final diagnoses were bacterial pneumonia (29%), Pneumocystis jirovecii pneumonia (27%), pulmonary tuberculosis (22%), and pulmonary Kaposi's sarcoma (16%); 39 (77%) of these cases were confirmed cases. Fifteen (29%) patients had multiple isolates. At least 3 of 11 viral-positive polymerase chain reaction (PCR) results of bronchoalveolar lavage fluid were attributed clinical relevance. No atypical bacterial organisms were found. Copyright

Additional Metadata
Persistent URL,
Hartung, T.K., Chimbayo, D., van Oosterhout, J.J.G., Chikaonda, T., van Doornum, G.J.J., Claas, E.C.J., … Zijlstra, E.. (2011). Etiology of suspected pneumonia in adults admitted to a high-dependency unit in Blantyre, Malawi. American Journal of Tropical Medicine and Hygiene, 85(1), 105–112. doi:10.4269/ajtmh.2011.10-0640