A synthetic peptide derived from the animo acid sequence of canine parvovirus structural proteins which defines a B cell epitope and elicits antiviral antibody in BALB c mice.
Synthetic peptides, recombinant fusion proteins and mouse monoclonal antibodies were used to delineate a B cell epitope of the VP'2 structural protein of canine parvovirus (CPV). Although this epitope is not preferentially recognized in the normal antibody response to CPV, virus-specific antibodies could be induced in BALB/c mice with a synthetic peptide representing the epitope. The potential of this non-dominant B cell epitope to induce antiviral immunity in the presence of maternal CPV-specific antibodies, is discussed.
|Keywords||0 (Antibodies, Monoclonal), 0 (Antibodies, Viral), 0 (Epitopes), 0 (Recombinant Fusion Proteins), 0 (Viral Proteins), Animals, Antibodies, Monoclonal/immunology, Antibodies, Viral/biosynthesis, B-Lymphocytes/*immunology, Dogs, Epitopes, Mice, Mice, Inbred BALB C, Parvoviridae/*immunology, Recombinant Fusion Proteins/immunology, Support, Non-U.S. Gov't, Viral Proteins/*immunology|
Rimmelzwaan, G.F., Carlson, J., Uytdehaag, F.G.C.M., & Osterhaus, A.D.M.E.. (1990). A synthetic peptide derived from the animo acid sequence of canine parvovirus structural proteins which defines a B cell epitope and elicits antiviral antibody in BALB c mice.. Journal of General Virology, 71, 2741–2745. Retrieved from http://hdl.handle.net/1765/3410