Cysteine-rich secretory protein 3 and β-microseminoprotein on prostate cancer needle biopsies do not have predictive value for subsequent prostatectomy outcome
What's known on the subject? and What does the study add? Cysteine-rich secretory protein 3 (CRISP-3) and β-microseminoprotein (β-MSP) both have independent prognostic value for biochemical recurrence of prostate cancer after radical prostatectomy. The study investigates whether CRISP-3 and β-MSP have prognostic value on diagnostic prostate needle-biopsies, which are more relevant for therapeutic decision-making. On needle-biopsies CRISP-3 and β-MSP do not have significant prognostic value. OBJECTIVES • To investigate whether cysteine-rich secretory protein 3 (CRISP-3) and/or β-microseminoprotein (β-MSP) expression in diagnostic prostate needle biopsies have predictive value for prostate cancer (PC) on radical prostatecomy (RP). • To evaluate their potential clinical implementation in a preoperative setting. PATIENTS AND METHODS • In total, 174 participants from the European Randomized Study of Screening for Prostate Cancer, Rotterdam section, treated by RP for PC were included in the present study. • CRISP-3 and β-MSP immunohistochemistry was performed on corresponding diagnostic needle biopsies. • Outcome was correlated with clinicopathological parameters (prostate-specific-antigen, PSA; number of positive biopsies; Gleason score, GS; pT-stage; surgical margins at RP) and significant PC at RP (pT3/4, or GS > 6, or tumour volume ≥0.5 mL) in the total cohort (n= 174) and in a subgroup with low-risk features at biopsy (PSA ≤ 10 ng/ml, cT a;circ 2, PSA density <0.20 ng/mL/g, GS < 7 and ≤2 positive biopsy cores; n= 87). RESULTS âcent β-MSP and CRISP-3 expression in PC tissue was heterogeneous, with variable staining intensities occurring in the same tissue specimen. âcent High expression of β-MSP significantly correlated with GS < 7 at RP; it was not a predictor for significant PC at RP neither in the total group (n= 174; odds ratio, OR, 0.319; 95% confidence interval, CI, 0.060-1.695; P= 0.180), nor in the low-risk group (n= 87; OR, 0.227; 95% CI, 0.040-1.274; P= 0.092). âcent CRISP-3 expression was not related to clinicopathological parameters, and did not predict significant PC at RP in the total group (n= 174; OR, 1.056; 95% CI, 0.438-2.545; P= 0.904) or the low-risk group (n= 87; OR, 1.856; 95% CI, 0.626-5.506; P= 0.265). CONCLUSIONS âcent High β-MSP expression correlated with low GS in subsequent RP specimens, supporting the view that β-MSP exerts a tumour-suppressive effect. âcent No significant prognostic value of β-MSP or CRISP-3 in prostate needle biopsies for significant PC at RP was found. âcent β-MSP or CRISP-3 do not have additional value in the therapeutic stratification of patients with PC.
|Keywords||CRISP-3, biomarker, prognosis, prostate cancer, β-MSP|
|Persistent URL||dx.doi.org/10.1111/j.1464-410X.2010.10059.x, hdl.handle.net/1765/34356|
Hoogland, A.M., Dahlman, A., Vissers, K.J., Tineke, T., Schröder, F.H., Roobol, M.J., … Leenders, G.J.. (2011). Cysteine-rich secretory protein 3 and β-microseminoprotein on prostate cancer needle biopsies do not have predictive value for subsequent prostatectomy outcome. BJU International, 108(8), 1356–1362. doi:10.1111/j.1464-410X.2010.10059.x