Two different mutations in the envelope protein of feline immunodeficiency virus allow the virus to escape from neutralization by feline serum antibodies
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Cited by (11)
Mutations in the feline immunodeficiency virus envelope glycoprotein confer resistance to a dominant-negative fragment of Tsg101 by enhancing infectivity and cell-to-cell virus transmission
2014, Biochimica et Biophysica Acta - BiomembranesCitation Excerpt :We had initially speculated the acquisition of TSG-5′-resistance by mutation of FIV Env (K410N) in the V3 loop would possibly affect virion binding affinity to CXCR4 and HSPGs, either positively or negatively, based on the reported correlations between overall net charge in this region and coreceptor affinity [65,90]. It has been shown that the net charge in the V3 loop differs between lab-adapted isolates grown in cell culture and primary isolates obtained from infected cats, which is actively maintained by selective pressures in both environments [68–70,91]. Since our study focused on FIV replication mediated by CD134-independent entry, the selection for resistance may have favored mutations in the HSPG or CXCR4-binding regions of FIV Env that are more highly utilized by the 34TF10 molecular clone.
Mutations in feline immunodeficiency (FIV) virus envelope gene V3-V5 regions in FIV-infected cats
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2013, Veterinary RecordNeutralization of feline immunodeficiency virus by antibodies targeting the V5 loop of Env
2010, Journal of General Virology