In vitro and in vivo replication of seal gammaherpesviruses in cells of multiple species
Phocid herpesvirus virus type 2 (PhHV-2), a putative gammaherpesvirus of seals, has been isolated from harbor seals (Phoca vitulina) and grey seals (Halichoerus grypus). In the present study, different PhHV-2 isolates were shown to have a broad in vitro tropism for various cell types from several mammalian species. Inbred mice and two species of non-human primates proved to be susceptible to experimental infection with PhHV-2. The development of myoepitheliomas and spleen hyperplasia upon cyclosporin A treatment in some of the PhHV-2-infected animals warrants further investigation of the oncogenic and zoonotic potential of this virus.
|Keywords||Gammaherpesvirus, Mouse, Myoepithelioma, Phocid herpesvirus type 2, Primate, Seal, Spleen hyperplasia, Tropism, Zoonosis|
|Persistent URL||dx.doi.org/10.1016/j.micinf.2006.10.006, hdl.handle.net/1765/36746|
Martina, B.E.E., Verjans, G.M.G.M., Kuiken, T., van Amerongen, G., & Osterhaus, A.D.M.E.. (2007). In vitro and in vivo replication of seal gammaherpesviruses in cells of multiple species. Microbes and Infection: a journal on infectious agents and host defenses, 9(1), 40–46. doi:10.1016/j.micinf.2006.10.006