Molecular Profiling of Gliomas
Gliomas are the most common type of primary brain tumors in adults with an incidence rate of 5.27 per 100.000 patients every year 1-2. In 1926, Bailey and Cushing suggested a classification model based on distinct histological morphologies 3, which forms the basis of the currently used WHO classification 1. Two major subtypes are recognized: Astrocytic (A) and oligodendrocytic (OD) tumors, the latter including pure OD tumors and mixed oligoastrocytic (MOA) tumors. Astrocytic tumors are further separated into grades I (pilocytic astrocytomas [PA]), II (low grade), III (anaplastic), and IV (glioblastoma [GBM]). Oligodendrocytic tumors are further separated into grades II (low grade) and III (anaplastic). Patient survival, time to tumor progression, and response to therapy are all associated with subtype and grade of the tumor 1. This classification model, combined with the patients’ prognostic features (e.g. age and Karnofsky Performance Score [KPS]), guides treatment decisions.
|Keywords||brain tumors, gliomas, histologic diagnoses|
|Promotor||Bent, M.J. van den (Martin)|
|Publisher||Erasmus MC: University Medical Center Rotterdam|
Gravendeel, A.M.. (2012, October 10). Molecular Profiling of Gliomas. Erasmus MC: University Medical Center Rotterdam. Retrieved from http://hdl.handle.net/1765/37474