The influenza A virus is one of the leading causes of respiratory tract infections in humans. Upon infection with an influenza A virus, both innate and adaptive immune responses are induced. Here we discuss various strategies used by influenza A viruses to evade innate immune responses and recognition by components of the humoral and cellular immune response, which consequently may result in reduced clearing of the virus and virus-infected cells. Finally, we discuss how the current knowledge about immune evasion can be used to improve influenza A vaccination strategies.

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doi.org/10.3390/v4091438, hdl.handle.net/1765/39047
Viruses
Erasmus MC: University Medical Center Rotterdam

van de Sandt, C., Kreijtz, J., & Rimmelzwaan, G. (2012). Evasion of influenza A viruses from innate and adaptive immune responses. Viruses (Vol. 4, pp. 1438–1476). doi:10.3390/v4091438