The present study is a non-concurrent prospective cohort study on the risks of the Crowe therapy in 2,542 subjects who underwent this treatment compared to 2,380 - similar - non-irradiated control subjects. The study population consisted of patients from five Dutch ENT clinics. The follow-up period was 25 years. This study aims to answer the following questions: l. Does exposure to the Crowe therapy induce tumours? In this case attention is particularly focussed on the possibility of an increase in mortality and/ or incidence of tumours in the head and neck region, namely nasopharyngeal and brain tumours. 2. Does the Crowe therapy have any influence on hormone dependant processes, such as growth, fertility and hormone dependant diseases, owing to the irradiation of the pituitary gland? Additional aims of the study are: 3. To gather data in order to better determine the dose-effect relationship in the exposure range 0-50 cGy, an area in which little is known on man. 4. To study the follow-up procedures involved with non-concurrent prospective cohort studies on clinical populations in the Netherlands.

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Het onderzoek kon worden uitgevoerd door financiele steun van het Ministerie van Onderwijs en Wetenschappen, het Koningin Wilhelmina Fonds en het Klinisch Genootschap Zuid-Limburg. De uitgave van dit proefschrift werd financieel gesteund door Beecham Research Laboratories, Entermed B.V., Glaxo B.V. (vertaling), lnpharzam Nederland N.V., Lederle Nederland B.V., Sarva-Syntex Nederland, Stopler lnstrumenten en Apparaten B. V. en Streukens Hoorapparaten B. V.
P.J. van der Maas (Paul)
Erasmus University Rotterdam
hdl.handle.net/1765/40260
Erasmus MC: University Medical Center Rotterdam

Verduijn, P. G. (1988, June 15). Late health effects of radiation for eustachian tube dysfunction : a non-concurrent prospective study. Retrieved from http://hdl.handle.net/1765/40260