The vasodilatory action of molsidomine was studied by intracoronary injection of its active metabolite, Sin 1. In 10 patients repeat coronary angiography in multiple projections was performed before and 2 minutes after administration of 1 mg of Sin 1, and before and after a second injection 60 minutes later. Contours of obstructed and non-obstructed segments of the left coronary artery were quantitatively analysed with a computer-based angiography analysis system. Immediately after its administration, Sin 1 increased the mean diameters of 44 normal coronary segments by 12% (P less than 0.001). Significant vasodilation (8%) was still observed after 60 minutes. At that time, repeated administration of Sin 1 increased the vasodilation by an additional 14% with respect to the control situation. An increase in obstruction diameter was observed in 6 out of 8 obstructed segments. Mean increase in the minimal obstruction diameter was still 10% after 60 minutes.

Additional Metadata
Keywords 0 (Vasodilator Agents), 25717-80-0 (Molsidomine), 33876-97-0 (3-morpholino-sydnonimine), Coronary Angiography, Coronary Disease/*drug therapy/radiography, Coronary Vessels/*drug effects, Human, Injections, Intra-Arterial, Molsidomine/administration & dosage/*analogs & derivatives/therapeutic use, Support, Non-U.S. Gov't, Time Factors, Vasodilator Agents/administration & dosage/*therapeutic use
Persistent URL hdl.handle.net/1765/4252
Citation
Serruys, P.W.J.C., Luijten, H.E., Reiber, J.H.C., Tijssen, J.G.P., Chadha, D., Hugenholtz, P.G., & Deckers, J.W.. (1987). Long-acting coronary vasodilatory action of the molsidomine metabolite Sin I: a quantitative angiographic study. European Heart Journal, 8, 263–270. Retrieved from http://hdl.handle.net/1765/4252