Recovery of regional myocardial dysfunction after successful coronary angioplasty early after a non-Q wave myocardial infarction
More aggressive therapy has been suggested for patients who have a non-Q wave myocardial infarction (MI) because of the frequency of subsequent unstable angina, recurrent MI, and high mortality rate compared to patients with Q wave MI. The present study was undertaken to investigate the effect of coronary angioplasty on regional myocardial function of the infarct zone in patients with angina early after a non-Q wave MI. The study population consisted of 36 patients undergoing successful coronary angioplasty within 30 days of a non-Q wave MI, in whom sequential left ventricular angiograms of adequate quality were obtained before the initial procedure and at follow-up angiography. The global ejection fraction increased significantly from 60 +/- 9% to 67 +/- 6% (p = 0.0003). This significant increase in the global ejection fraction was primarily due to a significant improvement in the regional myocardial function of the infarct zone. The results of the present study show not only that ischemic attacks early after a non-Q wave MI may lead to prolonged regional myocardial dysfunction but more important that this depressed myocardium has the potential to achieve normal contraction after successful coronary angioplasty.
|Keywords||*Angioplasty, Transluminal, Percutaneous Coronary, 0 (Thallium Radioisotopes), Angiography, Electrocardiography, Exercise Test, Heart/*physiopathology, Human, Myocardial Infarction/physiopathology/radiography/*therapy, Thallium Radioisotopes/diagnostic use, Time Factors|
Suryapranata, H., Serruys, P.W.J.C., Beatt, K.J., de Feyter, P.J., van den Brand, M.J.B.M., & Roelandt, J.R.T.C.. (1990). Recovery of regional myocardial dysfunction after successful coronary angioplasty early after a non-Q wave myocardial infarction. American Heart Journal, 120(2), 261–269. Retrieved from http://hdl.handle.net/1765/4384