The treatment of ISR remains a therapeutic challenge, since many pharmacological and mechanical approaches have shown disappointing results. The SESs have been reported to be effective in de-novo coronary lesions.

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Keywords Coronary artery disease, sirolimus eluting stent
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Degertekin, M., Regar, E.S., Tanabe, K., Smits, P.C., van der Giessen, W.J., Carlier, S.G., … de Feyter, P.J.. (2003). Sirolimus-eluting stent for treatment of complex in-stent restenosis: the first clinical experience.. Journal of the American College of Cardiology, 41(2), 184–189. doi:10.1016/S0735-1097(02)02704-3