The treatment of ISR remains a therapeutic challenge, since many pharmacological and mechanical approaches have shown disappointing results. The SESs have been reported to be effective in de-novo coronary lesions.

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doi.org/10.1016/S0735-1097(02)02704-3, hdl.handle.net/1765/4744
Journal of the American College of Cardiology
Erasmus MC: University Medical Center Rotterdam

Degertekin, M., Regar, E., Tanabe, K., Smits, P., van der Giessen, W., Carlier, S., … de Feyter, P. (2003). Sirolimus-eluting stent for treatment of complex in-stent restenosis: the first clinical experience. Journal of the American College of Cardiology, 41(2), 184–189. doi:10.1016/S0735-1097(02)02704-3