2009-02-01
STrengthening the REporting of genetic association studies (STREGA)-an extension of the strobe statement
Publication
Publication
PLoS Medicine , Volume 6 - Issue 2 p. 0151- 0163
Summary
Making sense of rapidly evolving evidence on genetic
associations is crucial to making genuine advances in human
genomics and the eventual integration of this information
in the practice of medicine and public health. Assessment of
the strengths and weaknesses of this evidence, and hence
the ability to synthesize it, has been limited by inadequate
reporting of results. The STrengthening the REporting of
Genetic Association studies (STREGA) initiative builds on the
Strengthening the Reporting of Observational Studies in
Epidemiology (STROBE) Statement and provides additions
to 12 of the 22 items on the STROBE checklist. The additions
concern population stratification, genotyping errors, modelling
haplotype variation, Hardy-Weinberg equilibrium, replication,
selection of participants, rationale for choice of genes and
variants, treatment effects in studying quantitative traits,
statistical methods, relatedness, reporting of descriptive
and outcome data, and the volume of data issues that are
important to consider in genetic association studies. The STREGA
recommendations do not prescribe or dictate how a genetic
association study should be designed but seek to enhance the
transparency of its reporting, regardless of choices made during
design, conduct, or analysis.
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doi.org/10.1371/journal.pmed.1000022, hdl.handle.net/1765/50806 | |
PLoS Medicine | |
Little, J., Higgins, J., Ioannidis, J., Moher, D., Gagnon, F., von Elm, E., … Birkett, N. (2009). STrengthening the REporting of genetic association studies (STREGA)-an extension of the strobe statement. PLoS Medicine (Vol. 6, pp. 0151–0163). doi:10.1371/journal.pmed.1000022 |