Using resident peritoneal macrophages, this study was focussed on the activating role of endogenous leukotrienes in the regulation of macrophage antitumor cytostatic activity in response to inflammatory stimuli. Inhibitors and inducers of leukotrienes synthesis were used to modulate the macrophage antitumor cytostatic function and to identify the essential leukotriene(s) and enzymes involved in inhibition of tumor cell growth by activated macrophages. Induction of high macrophage antitumor activity by modulation of leukotriene biosynthesis might represent an efficient immunotherapeutic tool. - The main aim of the present work was to study the possible interrelationship between induction of antitumor cytostasis and of production of prostanoids and leukotrienes by murine peritoneal macrophages stimulated with the calcium ionophore A23187. A method of cell separation by velocity sed~mentation was adapted for obtaining macrophage-enriched preparations from the resident peritoneal macrophage population

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Erasmus University Rotterdam
I.L. Bonta
hdl.handle.net/1765/50840
Erasmus MC: University Medical Center Rotterdam

van Hilten, J. (1990, May 17). Modulation of macrophage antitumor cytostasis by endogenous leukotrienes. Retrieved from http://hdl.handle.net/1765/50840