Abstract

Covering the ends of the long bones in articular joints, cartilage allows smooth, gliding movement of the joints and distributes load evenly across the joint surface. Lesions in the articular cartilage are a major cause of discomfort and disability, especially in the aging population. Cartilage damage can be sub-divided roughly in 2 categories: focal cartilage defects that are for example due to trauma and degenerative cartilage damage in diseases such as osteoarthritis (OA). It is generally believed that untreated focal cartilage defects progress towards OA. Apart from the quest for treatments for OA, orthopaedic research is also focusing on the prevention of early OA by developing treatments for focal cartilage lesions.

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G.J.V.M. van Osch (Gerjo) , J.A.N. Verhaar (Jan)
Erasmus University Rotterdam
The printing of this thesis was financially supported by: Erasmus MC, department of Orthopaedics Erasmus Universiteit Rotterdam Anna Fonds, Leiden Nederlandse Vereniging voor Matrixbiologie The research leading to the results described in this thesis was financially supported by the European Union’s 7th Framework Programme under grant agreement no. NMP3-SL-2010-245993. The research in this thesis was performed within the framework of the Erasmus Postgraduate School Molecular Medicine. The word clouds displayed in thesis were generated using wordle.net
hdl.handle.net/1765/50842
Erasmus MC: University Medical Center Rotterdam

de Vries-Van Melle, M. (2014, March 27). In Vitro Models For Cell-Based Cartilage Regeneration. Retrieved from http://hdl.handle.net/1765/50842