1995
Hyposensitization in nickel allergic contact dermatitis: Clinical and immunologic monitoring
Publication
Publication
American Academy of Dermatology. Journal , Volume 32 - Issue 4 p. 576- 583
Background: In allergic contact dermatitis (ACD) previously sensitized T cells cause skin damage. If an ubiquitous allergen such as nickel is involved, no effective treatment is available. Down-regulation of this allergic response has been described after antigen presentation in the absence of adequate costimulatory signals. UV exposure can enhance such hyposensitization. Objective: The aim of this study was to establish the capability of a hyposensitization procedure to induce antigen-specific tolerance. Methods: Twenty-one patients with nickel ACD were randomly assigned to either a hyposensitized or control group. A schedule consisting of UVB treatment and subcutaneous nickel sulfate administration (hyposensitization) or UVB only (control) was applied. During the ensuing 2 years, several clinical and immunologic features were monitored. Results: During UVB treatment we observed a singificant clinical improvement in both groups that persisted in the hyposensitized group. Except for incresed slope variances of specific lymphocyte proliferation in time, no clear changes were seen in the immunologic findings. Conclusion: Despite significant clinical improvement induced by UVB, hyposensitization did not induce significant changes in the immunologic findings in patients with nickel ACD.
| Additional Metadata | |
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| doi.org/10.1016/0190-9622(95)90340-2, hdl.handle.net/1765/54958 | |
| American Academy of Dermatology. Journal | |
| Organisation | Department of Dermatology |
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Troost, R., Kozel, M. M. A., van Helden-Meeuwsen, C., van Joost, T., Mulder, P., Benner, R., & Prens, E. (1995). Hyposensitization in nickel allergic contact dermatitis: Clinical and immunologic monitoring. American Academy of Dermatology. Journal, 32(4), 576–583. doi:10.1016/0190-9622(95)90340-2 |
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