We studied nosocomial infections due to Mycobacterium bovis bacille Calmette-Guérin (BCG) Onco-TICE bacteria, transmitted by contamination of medication prepared in BCG Onco-TICE-contaminated hoods in the pharmacy, in 5 immunocompromised patients at 3 hospitals. The BCG strains cultured from the patients had the same DNA profile as the BCG Onco-TICE strain used for bladder instillation. To prevent these infections, a change from open to closed preparation was made; strictly separated preparation in time of BCG Onco-TICE instillation and chemotherapy was enforced, the biological safety cabinet was disinfected between preparations, and gloves were changed between preparations.

doi.org/10.1086/379034, hdl.handle.net/1765/56568
The Journal of Infectious Diseases
Department of Pharmacy

Vos, M., Haas, P., Verbrugh, H., Renders, N., Hartwig, N., de Man, P., … van Soolingen, D. (2003). Nosocomial Mycobacterium bovis-Bacille Calmette-Guérin Infections Due to Contamination of Chemotherapeutics: Case Finding and Route of Transmission. The Journal of Infectious Diseases, 188(9), 1332–1335. doi:10.1086/379034