2001-11-12
Endocytic disturbances distinguish among subtypes of Alzheimer's disease and related disorders
Publication
Publication
Annals of Neurology , Volume 50 - Issue 5 p. 661- 665
The endocytic pathway is important in amyloid precursor protein (APP) processing and β-amyloid formation. Our studies have shown that endocytic pathway activation is a prominent and early feature of neurons in vulnerable regions of the brain in sporadic Alzheimer's disease. We report that endocytic pathway abnormalities are present not only in neurons, but in cerebral endothelia in Alzheimer's disease caused by certain APP mutations. The presence or absence of endocytic abnormalities distinguish subtypes of familial Alzheimer's disease linked to APP mutations from presenilin mutations, supporting the notion that different cellular pathways are involved in the altered processing of APP leading to increased β-amyloid generation in certain of these different Alzheimer's disease subtypes.
Additional Metadata | |
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doi.org/10.1002/ana.1254, hdl.handle.net/1765/58109 | |
Annals of Neurology | |
Organisation | Erasmus MC: University Medical Center Rotterdam |
Cataldo, A., Rebeck, W., Ghetti, B., Hulette, C., Lippa, C., van Broeckhoven, C., … Nixon, R. (2001). Endocytic disturbances distinguish among subtypes of Alzheimer's disease and related disorders. Annals of Neurology, 50(5), 661–665. doi:10.1002/ana.1254 |