2012-09-01
Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes
Publication
Publication
Nature Genetics , Volume 44 - Issue 9 p. 981- 990
To extend understanding of the genetic architecture and molecular basis of type 2 diabetes (T2D), we conducted a meta-analysis of genetic variants on the Metabochip, including 34,840 cases and 114,981 controls, overwhelmingly of European descent. We identified ten previously unreported T2D susceptibility loci, including two showing sex-differentiated association. Genome-wide analyses of these data are consistent with a long tail of additional common variant loci explaining much of the variation in susceptibility to T2D. Exploration of the enlarged set of susceptibility loci implicates several processes, including CREBBP-related transcription, adipocytokine signaling and cell cycle regulation, in diabetes pathogenesis.
Additional Metadata | |
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doi.org/10.1038/ng.2383, hdl.handle.net/1765/58733 | |
Nature Genetics | |
Organisation | Department of Surgery |
Morris, A., Voight, B., Teslovich, T., Ferreira, T., Segrè, A., Steinthorsdottir, V., … McCarthy, M. (2012). Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. Nature Genetics, 44(9), 981–990. doi:10.1038/ng.2383 |