Angiotensin-converting enzyme gene polymorphism and carotid artery wall thickness a meta-analysis.
BACKGROUND AND PURPOSE: Many studies have investigated the association between the angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism and carotid artery intima-media thickness (IMT); however, most studies were small and conducted in selective samples. The aim of this study was to evaluate this association by performing a meta-analysis on published articles. METHODS: We searched Medline for articles studying the association between the ACE I/D polymorphism and carotid IMT. Twenty-six studies were found; 23 articles containing 9833 subjects were qualified to enter the meta-analysis. We classified those articles on the basis of their samples into high-risk and low-risk populations and white and Asian ethnic groups. IMT was used as a continuous variable, and data were analyzed with the Cochrane Review Manager. RESULTS: A significant positive association was present between the D allele and common carotid IMT (weighted mean difference between DD and II genotypes, 0.23 mm x 10(-1); P<0.01). The association was stronger among high-risk populations. The point estimates of DD versus II were higher than those of ID versus II. CONCLUSIONS: Our meta-analysis showed evidence of a positive association between the D allele of the ACE gene and common carotid IMT. The overall results were concordant in both ethnic groups.
|Keywords||*Polymorphism (Genetics), Adult, Aged, Alleles, Asian Continental Ancestry Group/genetics, Carotid Arteries/*ultrasonography, EC 188.8.131.52 (Peptidyl-Dipeptidase A), European Continental Ancestry Group/genetics, Female, Gene Frequency, Human, Male, Middle Aged, Peptidyl-Dipeptidase A/*genetics, Risk, Support, Non-U.S. Gov't, Tunica Intima/ultrasonography, Tunica Media/ultrasonography, atherosclerosis, stroke|
|Note||Epub 2003 Jun 12|
|Persistent URL||dx.doi.org/10.1161/01.STR.0000077926.49330.64, hdl.handle.net/1765/5983|
Sayed-Tabatabaei, F.A., Houwing-Duistermaat, J.J., van Duijn, C.M., & Witteman, J.C.M.. (2003). Angiotensin-converting enzyme gene polymorphism and carotid artery wall thickness a meta-analysis.. Stroke, 34(7), 1634–1639. doi:10.1161/01.STR.0000077926.49330.64